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Fulminant type 1 diabetes, an underrecognized and unique subtype of type 1 diabetes: A case series from Singapore
Journal of Diabetes Investigation ( IF 3.2 ) Pub Date : 2024-03-06 , DOI: 10.1111/jdi.14160 Sarah Ying Tse Tan 1, 2 , Suresh Rama Chandran 1, 2 , Jielin Yew 3 , Andy Jun‐Wei Wong 1 , Daphne Su‐Lyn Gardner 1, 2
Journal of Diabetes Investigation ( IF 3.2 ) Pub Date : 2024-03-06 , DOI: 10.1111/jdi.14160 Sarah Ying Tse Tan 1, 2 , Suresh Rama Chandran 1, 2 , Jielin Yew 3 , Andy Jun‐Wei Wong 1 , Daphne Su‐Lyn Gardner 1, 2
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Fulminant type 1 diabetes (FT1D) is a unique subtype of type 1 diabetes, characterized by acute absolute insulin deficiency, severe ketosis, and increased risk of hypoglycemia, glycemic variability and microvascular complications. Seven people with FT1D were identified from two tertiary centers in Singapore. Six were Chinese, the mean age was 35 years and all were lean (mean body mass index 20.3 kg/m2 ). All presented with diabetes ketosis or ketoacidosis and low C‐peptide. All but one had low glutamic acid decarboxylase antibodies. Nearly half had a missed/delayed diagnosis of FT1D. Three had frequent hypoglycemia, which improved after transition to continuous subcutaneous insulin infusion therapy. Individuals with FT1D experience unique diagnostic and management challenges associated with rapid absolute insulin deficiency. Greater awareness about this clinical entity is required.
更新日期：2024-03-06
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