BackgroundMyocardial strain is a promising marker for the detection of early left or right ventricular (LV or RV) dysfunction in pediatric populations. The reference standard for MR strain measurement is myocardial tagging (MT); however, MT has limited clinical utility because the additional acquisitions needed are time‐consuming. In contrast, MR‐feature tracking (FT) allows strain quantification from routinely acquired cine sequences. Studies providing reference values obtained with both FT and MT for adolescents are lacking.PurposeTo use MR‐FT and MT to define sex‐specific LV and RV strain reference values for adolescents.Study TypeCross‐sectional, prospective.PopulationOne hundred twenty‐three adolescents aged 15–18 years (52% girls) without known cardiovascular disease.Field Strength/SequenceBalanced steady‐state free‐precession sequence for FT analysis and a spatial modulation of magnetization hybrid TFE‐EPI sequence for MT acquisitions at 3.0‐T.AssessmentSegment Medviso software was used to obtain longitudinal (LS) and circumferential (CS) strain for both ventricles, and radial strain (RS) for LV.Statistical TestsThe Student t‐test was used for between‐sex comparisons of continuous variables. Sex‐specific percentiles were calculated using the weighted average method. Intraobserver and interobserver agreement was assessed in 30 randomly selected studies using intraclass correlation coefficients (ICC). A P‐value <0.05 was considered statistically significant.ResultsFT‐derived LVLS and LVCS were significantly higher in girls than in boys (−19.8% vs. −17.8% and −22.2% vs. −21.0%, respectively), as they were with MT (LVLS: −18.1% vs. −16.8%; LVCS: −20.8% vs. −19.7%). FT‐LVRS was higher in girls than in boys (44.8% vs. 35.1%), while MT‐LVRS was the opposite (18.6% vs. 22.7%). FT‐RVLS was higher in girls (−23.4% vs. −21.3%), but there were no between‐sex differences in MT‐derived RVLS or RVCS. ICC values for intraobserver agreement were ≥0.89, whereas for interobserver agreement were <0.80 for MT‐LVRS and ≥0.80 for all remaining parameters.Data ConclusionThis study provides sex‐specific reference biventricular strain values obtained with MR‐MT and MR‐FT for adolescents aged 15–18 years. MR‐FT may be a valid method for obtaining strain values in pediatric populations.Evidence Level1Technical EfficacyStage 3

中文翻译：

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使用特征跟踪和心肌标记获得的 MR 衍生双心室应变的青少年参考值

背景心肌应变是检测儿童早期左心室或右心室（LV 或 RV）功能障碍的有前景的标志物。MR应变测量的参考标准是心肌标签（MT）；然而，MT 的临床实用性有限，因为所需的额外采集非常耗时。相比之下，MR 特征跟踪 (FT) 允许从常规获取的电影序列中进行应变量化。缺乏提供青少年 FT 和 MT 参考值的研究。目的使用 MR-FT 和 MT 定义青少年性别特异性 LV 和 RV 应变参考值。研究类型横断面、前瞻性。人口 123 岁青少年15-18 岁（52% 女孩）没有已知的心血管疾病。场强/序列平衡稳态自由进动序列用于 FT 分析和磁化混合 TFE-EPI 序列的空间调制用于 3.0-T 下的 MT 采集。评估麦维索段使用软件获得两个心室的纵向 (LS) 和周向 (CS) 应变以及 LV 的径向应变 (RS)。 统计测试The Studentt‐检验用于连续变量的性别间比较。使用加权平均法计算特定性别的百分位数。使用组内相关系数 (ICC) 在 30 项随机选择的研究中评估观察者内和观察者间的一致性。A磷‐值 <0.05 被认为有统计学意义。结果 FT 衍生的 LVLS 和 LVCS 在女孩中显着高于男孩（分别为 -19.8% vs. -17.8% 和 -22.2% vs. -21.0%），与 MT 相同（LVLS：-18.1% vs.-16.8%；LVCS：-20.8% vs.-19.7%）。女孩中 FT-LVRS 高于男孩（44.8% 比 35.1%），而 MT-LVRS 则相反（18.6% 比 22.7%）。女孩中的 FT-RVLS 较高（−23.4% vs. -21.3%），但 MT 衍生的 RVLS 或 RVCS 没有性别间差异。观察者内一致性的 ICC 值≥0.89，而观察者间一致性对于 MT-LVRS 小于 0.80，对于所有其余参数≥0.80。 数据结论本研究提供了通过 MR-MT 和 MR-FT 获得的青少年性别特异性参考双心室应变值年龄 15-18 岁。MR-FT 可能是获取儿科人群应变值的有效方法。证据级别 1 技术功效阶段 3