Cocrystallization can change the physicochemical and pharmacokinetic properties of active pharmaceutical ingredients (API) and improve biological activities. This study focuses on the documented biological activities of APIs in cocrystal form, specifically those with anticancer properties. Additionally, the mechanisms by which these APIs exhibit modified anticancer effects are discussed. Generally, this technique can change anticancer activity through solubilization, enhancing dissolution rate, permeability improvement, stabilization, producing a slow-release form, and retaining transient in solution and interaction with receptors.

中文翻译：

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共结晶提高药物抗癌活性

共结晶可以改变活性药物成分（API）的理化和药代动力学性质并提高生物活性。本研究重点关注已记录的共晶形式 API 的生物活性，特别是具有抗癌特性的 API。此外，还讨论了这些 API 表现出改变的抗癌作用的机制。一般来说，该技术可以通过增溶、提高溶出速率、改善渗透性、稳定化、产生缓释形式、在溶液中保持瞬时状态以及与受体的相互作用来改变抗癌活性。