Children with congenital heart disease (CHD) have a higher prevalence of motor impairment secondary to brain injury, resulting in cerebral palsy (CP). The purpose of this study is to determine the prevalence of CP in CHD in a single-center cohort, stratify risk based on surgical mortality using Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery (STAT) categories and identify risk factors. Retrospective cohort study of pediatric patients registered in the University of Florida (UF) Society of Thoracic Surgeons Congenital Heart Surgery database from 2006 to 2017 with a diagnosis of CHD who continued follow-up for more than two years at UF. A total of 701 children with CHD met inclusion criteria. Children identified to have CP were 54 (7.7%). Most common presentation was spastic hemiplegic CP with a Gross Motor Function Classification System of level 2. Analysis of surgical and intensive care factors between the two groups showed that children with CHD and CP had longer time from admission to surgery ( = 0.003), higher STAT categories 4 and 5 ( = 0.038), and higher frequency of brain injury and seizures ( < 0.001). Developmental disabilities and rehabilitation needs were significantly greater for children with CHD and CP when compared with those with CHD alone ( < 0.001). In our cohort, 7.7% children with CHD develop CP; this is significantly higher than the 2010 US population estimate of 0.3%. Our study suggests higher STAT categories, brain injury, and seizures are associated with developing CP in children with CHD.

中文翻译：

---

基于手术死亡风险的先天性心脏病儿童脑瘫的患病率和危险因素

患有先天性心脏病（CHD）的儿童继发于脑损伤的运动障碍的患病率较高，从而导致脑瘫（CP）。本研究的目的是确定单中心队列中 CHD 中 CP 的患病率，使用胸外科医生协会-欧洲心胸外科协会 (STAT) 类别根据手术死亡率对风险进行分层，并确定危险因素。这是一项回顾性队列研究，对象为 2006 年至 2017 年在佛罗里达大学 (UF) 胸外科医生协会先天性心脏病外科数据库中注册的诊断为 CHD 的儿科患者，并在 UF 继续随访了两年多。共有 701 名 CHD 儿童符合纳入标准。确诊患有 CP 的儿童为 54 名 (7.7%)。最常见的表现是痉挛性偏瘫 CP，粗大运动功能分类系统为 2 级。对两组之间的手术和重症监护因素的分析显示，患有 CHD 和 CP 的儿童从入院到手术的时间较长 (= 0.003)，STAT 较高类别 4 和类别 5 ( = 0.038)，脑损伤和癫痫发作的频率较高 ( < 0.001)。与仅患有 CHD 的儿童相比，患有 CHD 和 CP 的儿童的发育障碍和康复需求显着更大 ( < 0.001)。在我们的队列中，7.7% 的先心病儿童患有脑瘫；这明显高于 2010 年美国人口预测的 0.3%。我们的研究表明，较高的 STAT 类别、脑损伤和癫痫发作与先心病儿童发生脑瘫有关。