Background and ObjectivesWhile inpatient withdrawal management/acute stabilization can improve outcomes for individuals with opioid use disorder (OUD), patients often leave treatment early due to mood, tension, and cravings associated with opioid withdrawal. The aim of this study was to evaluate the feasibility and preliminary effectiveness of a novel virtual reality (VR) based intervention; 3D Therapy Thrive (3DTT).MethodsSubjects with OUD (N = 32) were recruited from a community acute stabilization program and received up to two sessions of 3DTT. They completed questionnaires related to their overall satisfaction with the experience and side effects; as well as those related to mood, tension, and cravings.ResultsThere were no reported side effects and the majority of subjects (94%) reported high satisfaction with the experience. Out of 62 patients approached, 33 patients agreed to participate (53%) 33 patients completed one, and 17 of these patients (52%) completed both sessions of 3DTT, with 19 participants (58%) completing their treatment protocols. Compared to baseline, 3DTT participants reported significant reductions in depression, tension, and cravings (p's < 0.001).Discussion and ConclusionsThis pilot study supports the feasibility and preliminary effectiveness of 3DTT for improving outcomes for inpatients with OUD. Future randomized controlled trials are necessary to evaluate the efficacy of 3DTT for improving retention, reducing cravings, and improving mood and tension.Scientific SignificanceThis is the first study to evaluate the feasibility of a psychologically informed VR intervention in inpatients with OUD.

中文翻译：

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针对阿片类药物使用障碍住院患者的虚拟现实试点研究

背景和目标虽然住院患者戒断管理/急性稳定可以改善阿片类药物使用障碍 (OUD) 患者的治疗结果，但患者常常由于与阿片类药物戒断相关的情绪、紧张和渴望而提前离开治疗。本研究的目的是评估基于虚拟现实（VR）的新型干预措施的可行性和初步有效性；3D 疗法蓬勃发展 (3DTT)。使用 OUD 的方法受试者 (氮= 32）是从社区急性稳定计划中招募的，并接受了最多两次 3DTT 治疗。他们完成了与体验和副作用总体满意度相关的调查问卷；以及与情绪、紧张和渴望相关的那些。结果没有报告副作用，大多数受试者 (94%) 报告对体验非常满意。在 62 名患者中，33 名患者同意参加 (53%)，33 名患者完成了一项，其中 17 名患者 (52%) 完成了 3DTT 的两次疗程，其中 19 名参与者 (58%) 完成了他们的治疗方案。与基线相比，3DTT 参与者的抑郁、紧张和渴望显着减少（p's < 0.001)。讨论和结论这项试点研究支持 3DTT 改善 OUD 住院患者预后的可行性和初步有效性。未来有必要进行随机对照试验来评估 3DTT 在提高记忆力、减少渴望以及改善情绪和紧张方面的功效。科学意义这是第一项评估对 OUD 住院患者进行心理知情 VR 干预的可行性的研究。