Modification effect of receipt of diabetes care on the association between COVID‐19 infection and HbA1c level during the first year of the coronavirus pandemic using a nationwide population‐based database,Journal of Diabetes Investigation

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Modification effect of receipt of diabetes care on the association between COVID‐19 infection and HbA1c level during the first year of the coronavirus pandemic using a nationwide population‐based database
Journal of Diabetes Investigation ( IF 3.1 ) Pub Date : 2024-03-02 , DOI: 10.1111/jdi.14171
Akira Okada ₁ , Satoko Yamaguchi ₁ , Sachiko Ono ₂ , Kayo Ikeda Kurakawa ₁ , Hideo Yasunaga ₃ , Masaomi Nangaku ₄ , Toshimasa Yamauchi ₅ , Takashi Kadowaki _{1,

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Affiliation

Aims/IntroductionWe assessed the modification effect of adherence to diabetes care on the association between HbA1c levels and the risk of coronavirus disease 2019 (COVID‐19) among individuals with diabetes using a population‐based database.Material and MethodsWe retrospectively identified individuals with diabetes during routine health checkups performed in 2019 in Japan using a population‐based claims database (JMDC, Tokyo, Japan). We assessed the risk of COVID‐19 infection in 2020 in relation to HbA1c levels during routine checkups, stratified by the presence/absence of follow‐up for diabetes care in 2019. Several sensitivity analyses were performed.ResultsWe identified 65,956 individuals with an HbA1c ≥6.5% and fasting glucose ≥126 mg/dL in routine checkups, including 52,637 and 13,319 with and without at least one physician consultation for diabetes care in 2019, respectively. Although high HbA1c levels were associated with an increased risk of COVID‐19 infection in a dose‐dependent manner among individuals without diabetes care in 2019 (odds ratios, 1.53 and 2.17 in individuals with HbA1c of 7.0–7.9% and ≥8.0%, respectively) with a reference to HbA1c of 6.5–6.9%, individuals with diabetes care had no such trend in 2019 (odds ratios, 0.99 and 0.97 among individuals with HbA1c of 7.0–7.9% and ≥8.0%, respectively). Sensitivity analyses yielded consistent results when the variable definitions were changed and after multivariable adjustment with multiple imputation.ConclusionsThis population‐based study suggests that adherence to diabetes care may modify the association between HbA1c levels and the risk of COVID‐19 infection.

中文翻译：

使用全国人口数据库，在冠状病毒大流行的第一年，接受糖尿病护理对 COVID-19 感染与 HbA1c 水平之间关联的影响

目的/简介我们使用基于人群的数据库评估了糖尿病患者中坚持糖尿病护理对 HbA1c 水平与 2019 年冠状病毒病 (COVID-19) 风险之间关系的修正效果。材料和方法我们回顾性地识别了糖尿病患者2019 年在日本使用基于人群的索赔数据库（JMDC，日本东京）进行的例行健康检查。我们评估了 2020 年 COVID-19 感染风险与常规检查期间 HbA1c 水平的关系，并根据 2019 年是否进行糖尿病护理随访进行分层。进行了多项敏感性分析。结果我们确定了 65,956 名 HbA1c ≥ 的个体例行检查中空腹血糖≥126 mg/dL 为 6.5%，其中 2019 年至少接受过一次糖尿病护理咨询的人数分别为 52,637 人和 13,319 人。尽管在 2019 年没有糖尿病护理的个体中，高 HbA1c 水平与 COVID-19 感染风险增加相关，且呈剂量依赖性（HbA1c 为 7.0-7.9% 和 ≥8.0% 的个体的比值比分别为 1.53 和 2.17））以 HbA1c 为 6.5-6.9% 为参考，接受糖尿病护理的个体在 2019 年没有这种趋势（HbA1c 为 7.0-7.9% 和 ≥8.0% 的个体的比值比分别为 0.99 和 0.97）。当变量定义发生变化以及经过多重插补的多变量调整后，敏感性分析得出了一致的结果。结论这项基于人群的研究表明，坚持糖尿病护理可能会改变 HbA1c 水平与 COVID-19 感染风险之间的关联。

更新日期：2024-03-02

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