Lymphocytes spanning the entire innate-adaptive spectrum can stably reside in tissues and constitute an integral component of the local defense network against immunological challenges. In tight interactions with the epithelium and endothelium, tissue-resident lymphocytes sense antigens and alarmins elicited by infectious microbes and abiotic stresses at barrier sites and mount effector responses to restore tissue homeostasis. Of note, such a host cell–directed immune defense system has been recently demonstrated to surveil epithelial cell transformation and carcinoma development, as well as cancer cell metastasis, at selected distant organs and thus represents a primordial cancer immune defense module. Here we review how distinct lineages of tissue-resident innate lymphoid cells, innate-like T cells, and adaptive T cells participate in a form of multilayered cancer immunity in murine models and patients, and how their convergent effector programs may be targeted through both shared and private regulatory pathways for cancer immunotherapy.Expected final online publication date for the Annual Review of Immunology, Volume 42 is April 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

中文翻译：

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癌症中组织驻留淋巴细胞的多层免疫

跨越整个先天适应性谱系的淋巴细胞可以稳定地驻留在组织中，并构成针对免疫挑战的局部防御网络的组成部分。在与上皮和内皮的紧密相互作用中，组织驻留淋巴细胞感知由传染性微生物和屏障位点的非生物应激引起的抗原和警报素，并产生效应反应以恢复组织稳态。值得注意的是，这种针对宿主细胞的免疫防御系统最近已被证明可以在选定的远处器官中监视上皮细胞转化和癌症发展以及癌细胞转移，因此代表了原始癌症免疫防御模块。在这里，我们回顾了组织驻留先天淋巴细胞、先天样 T 细胞和适应性 T 细胞的不同谱系如何参与小鼠模型和患者的多层癌症免疫形式，以及它们的汇聚效应程序如何通过共享的《免疫学年度评论》第 42 卷的预计最终在线发布日期为 2024 年 4 月。请参阅 http://www.annualreviews.org/page/journal/pubdates 了解修订后的估计。