The design of multifunctional hydrogel dressings to effectively promote wound healing is highly desirable in clinical trauma and surgery. Inspired by excellent mechanical properties of polyvinyl alcohol (PVA) and strong adhesion of polyphenols, gallic acid was grafted onto chitosan molecular chain (CS-GA) by free radical polymerization in this study, and PVA/CS-GA hydrogels were successfully prepared by repeated freeze-thaw method, without introducing toxic crosslinking agents. The prepared PVA/CS-GA hydrogels could adhere to various substrates, which confirmed excellent universal adhesion properties. The red blood cells adhesion ratio was 67.1%, indicating its potential for promoting wound coagulation. Meanwhile, the mechanical strength of PVA/CS-GA hydrogel was significantly enhanced, exhibiting approximately twice tensile strength and failure stretch compared with PVA hydrogel. Furthermore, attributing to GA molecule, PVA/CS-GA hydrogels not only showed favorable antibacterial activity against () and (), but also could scavenge free radicals, showing effective antioxidant activity. The hydrogels also had good biocompatibility, met the basic requirements of biomedical materials and may promote wound repair. It should be noted that the content of GA had significant impact on cytotoxicity. Therefore, multifunctional PVA/CS-GA hydrogels with excellent mechanical, adhesion, antioxidant, antibacterial and biocompatible properties show promising potential applications in the biomedicine field, especially as functional wound dressings.

中文翻译：

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冻融法制备多功能聚乙烯醇/没食子酸功能化壳聚糖水凝胶作为伤口敷料的潜在应用

有效促进伤口愈合的多功能水凝胶敷料的设计在临床创伤和手术中是非常需要的。本研究受聚乙烯醇（PVA）优异的机械性能和多酚的强粘附力的启发，通过自由基聚合将没食子酸接枝到壳聚糖分子链（CS-GA）上，并通过反复重复成功制备了PVA/CS-GA水凝胶。冻融法，不引入有毒交联剂。制备的 PVA/CS-GA 水凝胶可以粘附到各种基材上，这证实了其优异的通用粘附性能。红细胞粘附率为67.1%，表明其具有促进伤口凝血的潜力。同时，PVA/CS-GA水凝胶的机械强度显着增强，与PVA水凝胶相比，其拉伸强度和断裂伸长率约为两倍。此外，归因于GA分子，PVA/CS-GA水凝胶不仅对()和()表现出良好的抗菌活性，而且还可以清除自由基，表现出有效的抗氧化活性。该水凝胶还具有良好的生物相容性，满足生物医用材料的基本要求，并可促进伤口修复。值得注意的是，GA的含量对细胞毒性有显着影响。因此，具有优异机械性能、粘附性能、抗氧化性能、抗菌性能和生物相容性能的多功能PVA/CS-GA水凝胶在生物医学领域，特别是作为功能性伤口敷料，显示出良好的潜在应用前景。