Purpose

To evaluate the changes in macular structures following subthreshold micropulse laser (SHML) treatment for chronic central serous chorioretinopathy (cCSC).

Methods

Data of 33 eyes from 31 cCSC patients treated with SHML and followed up for at least 6 months has been included in this retrospective study. Main outcome measurements include resolution of subretinal fluid (SRF) and pigment epithelial detachment (PED), the recovery of ellipsoid zone (EZ) continuity, and the foveal outer nuclear layer (ONL) thickness along with its ratio.

Results

Mean observation period is 7.355 months (ranging from 6 to 24 months) and mean number of treatments administered is 1.839 (ranging from 1 to 5). 6 months after SHML treatment, there is a significant decrease in the area of SRF and PED (P < 0.001, P = 0.010, respectively). Additionally, the frequency of continuous EZ and the foveal ONL thickness reveal a significant increase (P<0.001, P = 0.005, respectively). The ratio of foveal ONL thickness is significantly higher after laser treatment, particularly in patients with a disease duration of ≤12 months (p = 0.022, P=0.036, respectively).

Conclusion

SHML treatment proves to be effective in cCSC eyes, leading to satisfactory recovery of macular structures, especially the photoreceptor layer.

中文翻译：

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阈下微脉冲激光治疗慢性中心性浆液性脉络膜视网膜病变后黄斑结构变化的评价

目的

评估阈下微脉冲激光 (SHML) 治疗慢性中心性浆液性脉络膜视网膜病变 (cCSC) 后黄斑结构的变化。

方法

这项回顾性研究纳入了接受 SHML 治疗并随访至少 6 个月的 31 名 cCSC 患者的 33 只眼睛的数据。主要结果测量包括视网膜下液（SRF）和色素上皮脱离（PED）的分辨率、椭球区（EZ）连续性的恢复以及中心凹外核层（ONL）厚度及其比率。

结果

平均观察期为 7.355 个月（范围为 6 至 24 个月），平均治疗次数为 1.839（范围为 1 至 5 次）。 SHML治疗6个月后，SRF和PED面积显着减小（分别为P < 0.001，P = 0.010）。此外，连续 EZ 的频率和中心凹 ONL 厚度显示显着增加（分别为P <0.001，P = 0.005）。激光治疗后中心凹ONL厚度比例显着升高，特别是病程≤12个月的患者（分别为p = 0.022、P = 0.036）。

结论

SHML 治疗被证明对 cCSC 眼睛有效，使黄斑结构（尤其是感光层）得到满意的恢复。