ObjectiveTo assess the prognostic values of hyperdense sign on pretreatment non-contrast head CT scan for successful recanalization (mTICI ≥2b) and 90-day good functional outcome (mRs 0-2) in patients with acute ischemic stroke undergoing mechanical thrombectomy (MT).MethodsLiterature search on PubMed, EMBASE, and Cochrane databases from inception up to 1 November 2023 was conducted. Twelve studies which reported hyperdense sign, recanalization and clinical outcomes were included in qualitative synthesis and meta-analysis.ResultsPooled analysis demonstrated a statistically significant association between successful recanalization and hyperdense sign-positive patients who underwent MT (odd ratios (OR) = 1.47, 95% confidence interval (CI) = 1.03–2.10, p = 0.04). No statistically significant association was demonstrated between presence of hyperdense sign and good functional outcome (OR = 1.04, 95% CI: 0.72–1.49, p = 0.85) or symptomatic intracranial hemorrhage sICH (OR: 1.80, 95% CI 0.72–4.47, p = 0.21)ConclusionsThis meta-analysis demonstrated that pre-intervention hyperdense sign on CT imaging might be useful in prediction of successful recanalization after MT.

中文翻译：

---

高密度征作为急性缺血性卒中成功再通和临床结果的预测因子：系统评价和荟萃分析

目的评估接受机械取栓（MT）的急性缺血性脑卒中患者治疗前平扫头部CT扫描高密度征对成功再通（mTICI≥2b）和90天良好功能结局（mRs 0-2）的预后价值。方法对 PubMed、EMBASE 和 Cochrane 数据库从建库到 2023 年 11 月 1 日期间进行文献检索。定性综合和荟萃分析中纳入了 12 项报告高密度征象、再通和临床结果的研究。结果汇总分析表明，成功再通和接受 MT 的高密度征阳性患者之间存在统计学显着相关性（比值比 (OR) = 1.47, 95） % 置信区间 (CI) = 1.03–2.10，p = 0.04）。高密度征的存在与良好的功能结果（OR = 1.04，95% CI：0.72-1.49，p = 0.85）或症状性颅内出血 sICH（OR：1.80，95% CI 0.72-4.47，p）之间没有统计学上的显着关联。 = 0.21）结论这项荟萃分析表明，干预前 CT 成像上的高密度征象可能有助于预测 MT 后成功的再通。