Point‐of‐collection testing (POCT) devices are widely used in roadside and workplace drug testing to identify recent cannabis use by measuring the presence of Δ9‐tetrahydrocannabinol (THC) in oral fluid (OF). However, the performance of POCT devices with oral medicinal cannabis products remains poorly described. In a randomised, double‐blinded, crossover trial, adults with insomnia disorder (n = 20) received a single (2 mL) oral dose of oil containing 10 mg THC + 200 mg cannabidiol, or placebo, prior to sleep. Participants were tested with the Securetec DrugWipe® 5S (10 ng/mL THC cut‐off) and Dräger DrugTest® 5000 (25 ng/mL THC cut‐off) POCT devices at baseline (pre‐treatment) and then at 0.5, 10, and 18 h post‐treatment. An OF sample, taken at each time point, was also analysed using liquid chromatography–tandem mass spectrometry. Large individual variability in OF THC concentrations was observed 0.5 h post‐treatment (range: 0–425 ng/mL; mean (SD) 48.7 (107.5) ng/mL). Both the Securetec DrugWipe® 5S and DrugTest® 5000 demonstrated poor sensitivity to THC at 0.5 h post‐treatment (25% and 50%, respectively). At 10 and 18 h post‐treatment, all participant OF THC concentrations were below screening cut‐offs, and all test results were negative. These findings highlight the relatively poor sensitivity of both devices in detecting recent use of an oral medicinal cannabis product. They also suggest a low probability of obtaining a positive THC result the morning after (‘one‐off’) use. Further research is required to establish the probability of obtaining a positive THC result with regular medicinal cannabis use.

中文翻译：

---

口服含有 THC 和大麻二酚的油后，使用两个收集点测试装置检测口腔液中的 Δ9-四氢大麻酚 (THC)

收集点测试 (POCT) 设备广泛用于路边和工作场所药物测试，通过测量 Δ 的存在来识别最近的大麻使用情况9‐口腔液（OF）中的四氢大麻酚（THC）。然而，口服药用大麻产品的 POCT 设备的性能仍知之甚少。在一项随机、双盲、交叉试验中，患有失眠症的成年人（n= 20) 在睡觉前接受单次 (2 mL) 口服剂量的含有 10 mg THC + 200 mg 大麻二酚的油或安慰剂。参与者在基线（治疗前）以及随后的 0.5、10、以及治疗后18小时。还使用液相色谱-串联质谱法对每个时间点采集的 OF 样品进行了分析。治疗后 0.5 小时观察到 OF THC 浓度存在较大个体差异（范围：0-425 ng/mL；平均值（标清) 48.7 (107.5) 纳克/毫升)。Securetec DrugWipe® 5S 和 DrugTest® 5000 在治疗后 0.5 小时时对 THC 的敏感性较差（分别为 25% 和 50%）。治疗后 10 和 18 小时，所有参与者的 THC 浓度均低于筛选临界值，并且所有测试结果均为阴性。这些发现突显了这两种设备在检测最近使用口服药用大麻产品时的灵敏度相对较差。他们还表明，在（“一次性”）使用后的第二天早上获得 THC 阳性结果的可能性很低。需要进一步的研究来确定定期使用药用大麻获得阳性 THC 结果的可能性。