NOS3 prevents MMP-9, and MMP-13 induced extracellular matrix proteolytic degradation through specific microRNA-targeted expression of extracellular matrix metalloproteinase inducer in hypertension-related atherosclerosis.,Journal of Hypertension

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NOS3 prevents MMP-9, and MMP-13 induced extracellular matrix proteolytic degradation through specific microRNA-targeted expression of extracellular matrix metalloproteinase inducer in hypertension-related atherosclerosis.
Journal of Hypertension ( IF 4.9 ) Pub Date : 2024-02-06 , DOI: 10.1097/hjh.0000000000003679
Rafael Ramírez-Carracedo ₁ , Ignacio Hernández _{1,

2} , Rafael Moreno-Gómez-Toledano _{1,

3} , Javier Díez-Mata ₁ , Laura Tesoro ₁ , Claudia González-Cucharero ₁ , Beatriz Jiménez-Guirado ₁ , Nunzio Alcharani ₁ , Laura Botana ₁ , Marta Saura _{2,

3} , Jose L. Zamorano _{2,

4} , Carlos Zaragoza _{1,

2}

Affiliation

Endothelial nitric oxide synthase (NOS3) elicits atheroprotection by preventing extracellular matrix (ECM) proteolytic degradation through inhibition of extracellular matrix metalloproteinase inducer (EMMPRIN) and collagenase MMP-13 by still unknown mechanisms.

中文翻译：

在高血压相关的动脉粥样硬化中，NOS3 通过细胞外基质金属蛋白酶诱导剂的特定 microRNA 靶向表达来防止 MMP-9 和 MMP-13 诱导的细胞外基质蛋白水解降解。

内皮一氧化氮合酶 (NOS3) 通过抑制细胞外基质金属蛋白酶诱导物 (EMMPRIN) 和胶原酶 MMP-13（机制尚不清楚）来防止细胞外基质 (ECM) 蛋白水解降解，从而引发动脉粥样硬化保护。

更新日期：2024-02-06

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