Burns can cause skin damage, facilitating the entry of fungi and other microorganisms into the body, leading to infections. Fusarium is a fungus capable of infecting individuals with burn injuries. Diagnosing and treating Fusarium infections in burn patients can be challenging due to the manifestation of nonspecific symptoms. This study aims to investigate case reports and case series from published literature describing Fusarium infection in burned patients, in order to assess treatment regimens, clinical outcomes, and make recommendations for future management. We conducted searches on Web of Science, PubMed, ScienceDirect, and Medline for all case reports and case series containing keywords ‘Burn’, ‘Burns’, ‘Burned’, ‘Fusarium’, or ‘Fusariosis’ in the title or abstract. All burns patients who developed Fusarium fungal infections between January 1974 and March 2023 were included in the study. Demographic and clinical data were analyzed retrospectivity. The final analysis incorporates 24 case reports encompassing a total of 87 burn patients with Fusarium infection. Patient ages ranged from one to 85 years, with the majority being male (53%). The median percentage of burn surface area was 78%, and the skin in the face upper limbs, and lower limbs were the most commonly infected sites. Fungal infections appeared around 10 days after the burn injury on average. The majority of the patients were identified through culture or histopathology. The Fusarium dimerum species complex (FDSC), which was found in nine patients, was the most frequently identified Fusarium species complex. Amphotericin B was the most preferred treatment drug, followed by voriconazole, and 62% of patients underwent debridement. In our study, 23 patients (37%) died from fungal infections. Implementing early and effective treatment protocols targeting Fusarium spp. in burn treatment units can significantly reduce mortality rates. It is critical to enhance the understanding of fusariosis epidemiology and emphasize the importance of maintaining a high clinical suspicion for this condition in burn patients.

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烧伤患者镰刀菌病：病例报告的系统回顾

烧伤会导致皮肤损伤，促进真菌和其他微生物进入体内，导致感染。镰刀菌是一种能够感染烧伤患者的真菌。由于烧伤患者表现出非特异性症状，诊断和治疗镰刀菌感染可能具有挑战性。本研究旨在调查已发表文献中描述烧伤患者镰刀菌感染的病例报告和病例系列，以评估治疗方案、临床结果，并为未来的治疗提出建议。我们在 Web of Science、PubMed、ScienceDirect 和 Medline 上搜索了标题或摘要中包含关键字“Burn”、“Burns”、“Burned”、“Fusarium”或“Fusariosis”的所有病例报告和病例系列。该研究纳入了 1974 年 1 月至 2023 年 3 月期间发生镰刀菌真菌感染的所有烧伤患者。对人口统计学和临床​​数据进行回顾性分析。最终分析包含 24 份病例报告，共 87 名镰刀菌感染烧伤患者。患者年龄从 1 岁到 85 岁不等，其中大多数为男性 (53%)。烧伤面积中位百分比为78%，面部皮肤、上肢和下肢是最常见的感染部位。真菌感染平均在烧伤后 10 天左右出现。大多数患者是通过培养或组织病理学鉴定的。在 9 名患者中发现的二聚镰刀菌属复合体 (FDSC) 是最常见的镰刀菌属复合体。两性霉素 B 是最优选的治疗药物，其次是伏立康唑，62% 的患者接受了清创术。在我们的研究中，23 名患者 (37%) 死于真菌感染。实施针对镰刀菌属的早期有效治疗方案。在烧伤治疗单位中可以显着降低死亡率。加强对镰刀菌病流行病学的了解并强调在烧伤患者中保持高度临床怀疑的重要性至关重要。