Background:We review the literature on the social impacts of diseases, defined as the social consequences of having a disease on the people around the patient, such as spouses, caregivers and offspring. The two objectives of this study are to summarise the social outcomes commonly associated with diseases and to compare the social impact across a range of diseases.Methods:A systematic review of the social impact of disease in Nordic countries was conducted using PubMed, PsycINFO and Google Scholar (PROSPERO registration number CRD42022291796). All articles that met the inclusion criteria were reviewed. We tabulated all outcomes and diseases studied, and synthesised the evidence based on the perspectives of patients, spouse/caregiver and offspring.Results:A total of 135 studies met the eligibility criteria, covering 76 diseases and 39 outcomes. From the patient’s perspective, diseases impact divorce and marriage rates, social functioning, likelihood of committing a crime and being a victim of crime. From the caregiver’s perspective, diseases affect their health-related quality of life and physical and psychological health. From the offspring’s perspective, diseases impact their development, health and social adversities in later life. Diseases generally had negative social impacts, but there were some diseases associated with positive impacts.Conclusions:The review provides a useful summary and gross comparison of the social impact of different diseases. The social impact of diseases can be large and significant. Thus, it should be considered when policymakers are setting priorities across disease areas.

中文翻译：

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北欧国家疾病社会影响的系统回顾

背景：我们回顾了有关疾病社会影响的文献，疾病的社会影响被定义为疾病对患者周围的人（例如配偶、照顾者和后代）造成的社会后果。本研究的两个目标是总结通常与疾病相关的社会结果，并比较一系列疾病的社会影响。方法：使用 PubMed、PsycINFO 和 Google 对北欧国家疾病的社会影响进行系统评价学者（PROSPERO 注册号 CRD42022291796）。所有符合纳入标准的文章均经过审查。我们将所有研究的结果和疾病制成表格，并根据患者、配偶/照顾者和后代的角度综合证据。结果：共有 135 项研究符合资格标准，涵盖 76 种疾病和 39 种结果。从患者的角度来看，疾病会影响离婚率和结婚率、社会功能、犯罪的可能性以及成为犯罪受害者的可能性。从护理人员的角度来看，疾病影响他们与健康相关的生活质量以及身心健康。从后代的角度来看，疾病会影响他们以后生活的发育、健康和社会逆境。疾病通常会产生负面的社会影响，但也有一些疾病会产生积极的社会影响。结论：该综述对不同疾病的社会影响进行了有益的总结和总体比较。疾病的社会影响可能是巨大且显着的。因此，决策者在确定跨疾病领域的优先事项时应考虑这一点。