Several series reported obstetric complications among pregnant women hospitalized for COVID. These data, because they focused on women with the most severe presentations or with specific immunosuppression, were likely to overestimate the risks associated with the infection at a global level. To date, population-based studies, most of which collected data from registers of women hospitalized during pregnancy for COVID-19, remain sparse. Neither the prevalence of COVID-19 in pregnant women nor the overall extent of obstetric complications worldwide, compared with uninfected pregnant women is clear. The impact of COVID-19 on perinatal care and obstetric management is thus difficult to evaluate. To evaluate the prevalence and determinants of COVID-19 diagnosis during pregnancy and assess related obstetric practices and perinatal outcomes. Used data collected at childbirth in France from women included in the 2021 national perinatal survey, we compared women with and without a COVID-19 diagnosis (for sociodemographic characteristics) and then women with no COVID-19 diagnosis during pregnancy, women diagnosed more than 15 days preceding childbirth, and those diagnosed within those 15 days for outcomes. The COVID-19 prevalence during pregnancy was 5.7 % (95 %CI 5.3–6.1) (678/11 930). The aOR for COVID-19 diagnosis associated with non-French nationality was 1.27 (95 %CI 1.03–1.58), with non-smoking 0.63 (95 %CI 0.55–0.81) and with multiparity 1.21 (95 %CI 1.02–1.45). Diagnosis occurred in the third trimester for 49 % —28.5 % in the 15 days before childbirth. Women with COVID-19 diagnosed during pregnancy had preterm births more often (9.6 %) than women without this diagnosis (6.9 %) ( = 0.007). Women with COVID-19 diagnosed within the 15 days preceding childbirth had more cesarean deliveries (28.3 %) than those diagnosed earlier (17.4 %) ( = 0.02). COVID-19 diagnosis during pregnancy was associated with an increased risk of preterm birth. Obstetric outcomes were poorer in women with a COVID-19 diagnosis in the 15 days preceding childbirth.

中文翻译：

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2021 年 3 月孕妇中 COVID-19 的患病率及其对分娩的影响：来自法国国家围产期调查的数据

多个系列报道了因新冠肺炎住院的孕妇的产科并发症。这些数据由于关注的是病情最严重或患有特定免疫抑制的女性，因此可能高估了全球范围内与感染相关的风险。迄今为止，基于人群的研究仍然很少，其中大部分收集的数据来自怀孕期间因 COVID-19 住院的妇女登记册。与未感染的孕妇相比，孕妇中 COVID-19 的患病率以及全球产科并发症的总体程度都不清楚。因此，COVID-19 对围产期护理和产科管理的影响很难评估。评估妊娠期间 COVID-19 诊断的患病率和决定因素，并评估相关的产科实践和围产期结局。使用 2021 年全国围产期调查中纳入的法国妇女分娩时收集的数据，我们比较了有和没有诊断出 COVID-19 的女性（社会人口学特征），然后比较了怀孕期间没有诊断出 COVID-19 的女性、诊断出超过 15 岁的女性分娩前几天，以及在这 15 天内诊断出结果的人。怀孕期间的 COVID-19 患病率为 5.7% (95%CI 5.3–6.1) (678/11 930)。与非法国国籍相关的 COVID-19 诊断的 aOR 为 1.27 (95%CI 1.03–1.58)，与非吸烟者相关的 aOR 为 0.63 (95%CI 0.55-0.81)，与多产相关的 aOR 为 1.21 (95%CI 1.02-1.45)。 49% —28.5% 的诊断发生在妊娠晚期，产前 15 天。怀孕期间诊断出患有 COVID-19 的女性早产率 (9.6%) 比未诊断出这种疾病的女性 (6.9%) 早产率更高 (= 0.007)。分娩前 15 天内诊断出患有 COVID-19 的女性的剖腹产率 (28.3%) 高于较早诊断出的女性 (17.4%) (= 0.02)。怀孕期间诊断出 COVID-19 与早产风险增加相关。在分娩前 15 天内诊断出 COVID-19 的女性的产科结果较差。