Bacteria are social microorganisms that use communication systems known as quorum sensing (QS) to regulate diverse cellular behaviors including the production of various secreted molecules. Bacterial secondary metabolites are widely studied for their bioactivities including antibiotic, antifungal, antiparasitic, and cytotoxic compounds. Besides playing a crucial role in natural bacterial niches and intermicrobial competition by targeting neighboring organisms and conferring survival advantages to the producer, these bioactive molecules may be of prime interest to develop new antimicrobials or anticancer therapies. This review focuses on bioactive compounds produced under acyl homoserine lactone-based QS regulation by Gram-negative bacteria that are pathogenic to humans and animals, including the Burkholderia, Serratia, Pseudomonas, Chromobacterium, and Pseudoalteromonas genera. The synthesis, regulation, chemical nature, biocidal effects, and potential applications of these identified toxic molecules are presented and discussed in light of their role in microbial interactions.

中文翻译：

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基于 AHL 的群体感应调节细菌中多种生物活性分子的生物合成

细菌是群居微生物，它们使用称为群体感应 (QS) 的通信系统来调节多种细胞行为，包括各种分泌分子的产生。细菌次生代谢物的生物活性被广泛研究，包括抗生素、抗真菌、抗寄生虫和细胞毒性化合物。除了通过靶向邻近生物体并赋予生产者生存优势，在天然细菌生态位和微生物间竞争中发挥关键作用外，这些生物活性分子可能对开发新的抗菌药物或抗癌疗法具有重要意义。本综述重点关注对人类和动物致病的革兰氏阴性菌（包括伯克霍尔德氏菌属、沙雷氏菌属、假单胞菌属、色杆菌属和假交替单胞菌属）在基于酰基高丝氨酸内酯的 QS 调节下产生的生物活性化合物。根据这些已确定的有毒分子在微生物相互作用中的作用，介绍并讨论了这些有毒分子的合成、调节、化学性质、杀菌作用和潜在应用。