This review aims to summarize pharmacological interventions that may affect adiposity and metabolic equilibrium in individuals with obesity. Pharmacological therapy is frequently used to treat medical conditions that are both directly related to obesity (such as hypertension and type 2 diabetes) and indirectly related to obesity (such as asthma, insomnia, and type 1 diabetes). This pharmacological therapy may result in weight gain and alterations in the metabolic profile. Many medication classes are implicated in the pharmacologic causes of weight gain, including antipsychotics, glucocorticoids, beta-adrenergic blockers, tricyclic antidepressants, antihistamines, insulin, neuropathic agents, sleep agents, and steroids. This article describes the mechanisms of action and pathways of pharmacological interventions causing obesity.

中文翻译：

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导致肥胖和肥胖相关疾病患者体重增加和代谢改变的药物治疗：综述

本综述旨在总结可能影响肥胖个体肥胖和代谢平衡的药物干预措施。药物治疗经常用于治疗与肥胖直接相关（例如高血压和 2 型糖尿病）以及与肥胖间接相关（例如哮喘、失眠和 1 型糖尿病）的疾病。这种药物治疗可能会导致体重增加和代谢特征改变。许多药物类别都与体重增加的药理学原因有关，包括抗精神病药、糖皮质激素、β-肾上腺素能阻滞剂、三环类抗抑郁药、抗组胺药、胰岛素、神经病药物、睡眠药物和类固醇。本文描述了导致肥胖的药物干预的作用机制和途径。