Wound healing can be a complex and slow process for the human body, particularly if it is chronic. Photothermal therapy (PTT) and photodynamic therapy (PDT) can be used to accelerate wound healing. As opposed to current PDT studies using well-known photosensitizers, this work use novel polyvinyl alcohol (PVA) and melanin nanoparticles (MNPs) containing hybrid nanofibers prepared by electrospinning techniques to enhance wound healing with/without UV light. Blend and core-sheath nozzles are utilized to obtain sustainable and biocompatible MNP-PVA blend, and core-sheath hybrid nanofibers and 30, 60, and 300 s of UV-A irradiation are tested in terms of photoinactivation efficiencies for Escherichia coli (E. coli). The MNP-PVA blend with a diameter of 324 nm and the core-sheath nanofibers with a diameter of 468 nm both showed killing effect on E. coli about 41.6% and 32%, respectively, under 30 s of UV-A irradiation. Increased irradiation time activates the protective effect of MNPs located in nanofibers, thereby decreasing photoinactivation efficiency. Moreover, the MNP-PVA core-sheath nanofibers with 30 s of UV-A irradiation promote the closure of wound to 99.2% at 24 h.

中文翻译：

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在 UV-A 照射下使用天然黑色素纳米颗粒-聚乙烯醇混合物和核鞘混合纳米纤维的组合疗法加速伤口愈合

对于人体来说，伤口愈合可能是一个复杂而缓慢的过程，尤其是慢性伤口愈合。光热疗法（PTT）和光动力疗法（PDT）可用于加速伤口愈合。与目前使用众所周知的光敏剂的 PDT 研究不同，这项工作使用新型聚乙烯醇 (PVA) 和含有通过静电纺丝技术制备的混合纳米纤维的黑色素纳米颗粒 (MNP)，以在有/无紫外线的情况下增强伤口愈合。利用共混和芯鞘喷嘴获得可持续且生物相容的 MNP-PVA 共混物，并测试了芯鞘混合纳米纤维和 30、60 和 300 秒的 UV-A 照射对大肠杆菌 (E. coli)的光灭活效率。大肠杆菌）。在30 s的UV-A照射下，直径为324 nm的MNP-PVA共混物和直径为468 nm的芯鞘纳米纤维对大肠杆菌的杀灭效果分别约为41.6%和32%。增加照射时间会激活位于纳米纤维中的 MNP 的保护作用，从而降低光灭活效率。此外，MNP-PVA核鞘纳米纤维在30秒的UV-A照射下，在24小时内促进伤口闭合至99.2%。