This research aims to examine the influence of human skull bone thickness and density on light penetration in PBM therapy across different wavelengths, focusing on how these bone characteristics affect the absorption of therapeutic light. Analyses explored the effect of skull bone density and thickness on light penetration in PBM, specifically using Low-Level Laser Therapy (LLLT) for efficacy prediction. Measurements of bone thickness and density were taken using precise tools. This approach emphasizes LLLT's significance in enhancing PBM outcomes by assessing how bone characteristics influence light penetration. The study revealed no significant correlation between skull bone density and thickness and light penetration capability in photobiomodulation (PBM) therapy, challenging initial expectations. Wavelengths of 405 nm and 665 nm showed stronger correlations with bone density, suggesting a significant yet weak impact. Conversely, wavelengths of 532 nm, 785 nm, 810 nm, 830 nm, 980 nm, and 1064 nm showed low correlations, indicating minimal impact from bone density variations. However, data variability (R² < 0.4) suggests that neither density nor thickness robustly predicts light power traversing the bone, indicating penetration capability might be more influenced by bone thickness at certain wavelengths. The study finds that the effectiveness of photobiomodulation (PBM) therapy with bone isn't just based on bone density and thickness but involves a complex interplay of factors. These include the bone's chemical and mineral composition, light's wavelength and energy dose, treatment duration and frequency, and the precise location where light is applied on the skull.

本研究旨在研究人类颅骨厚度和密度对不同波长的 PBM 治疗中光穿透的影响，重点研究这些骨骼特征如何影响治疗光的吸收。分析探讨了颅骨骨密度和厚度对 PBM 光穿透的影响，特别是使用低强度激光疗法 (LLLT) 进行疗效预测。使用精密工具测量骨厚度和密度。该方法通过评估骨骼特征如何影响光穿透来强调 LLLT 在增强 PBM 结果方面的重要性。该研究表明，光生物调节（PBM）治疗中颅骨骨密度和厚度与光穿透能力之间没有显着相关性，这挑战了最初的预期。 405 nm 和 665 nm 的波长与骨密度的相关性更强，表明影响显着但较弱。相反，532 nm、785 nm、810 nm、830 nm、980 nm 和 1064 nm 的波长显示出较低的相关性，表明骨密度变化的影响最小。然而，数据变异性（R ²  < 0.4）表明密度和厚度都不能可靠地预测穿过骨骼的光功率，这表明在某些波长下穿透能力可能更受骨骼厚度的影响。研究发现，骨光生物调节（PBM）疗法的有效性不仅仅取决于骨密度和厚度，还涉及多种因素的复杂相互作用。其中包括骨骼的化学和矿物质成分、光的波长和能量剂量、治疗持续时间和频率，以及光照射到头骨上的精确位置。