NOD-like receptor pyrin domain-containing 3 () is a cytosolic multi-protein complex that induces inflammation and is negatively regulated by progesterone. Previous researches have reported abnormal induction of reactive oxygen species (ROS) and progesterone resistance in endometriosis (EM). Since progesterone regulates ROS level and, consequently, inflammation, our objective is to investigate whether dienogest (DNG) regulates and whether the regulation of inflammasome by DNG in the blood plasma of patients with EM can affect oxidant and antioxidant markers. Plasma samples were obtained from control and EM patients experiencing pain symptoms to measure the level of , oxidants, and antioxidants. Subsequently, these patients were given oral DNG 2 mg/day for six months for drug treatment. After six months, plasma samples were collected from the patients for re-examination. The findings indicate that DNG reduced concentration and oxidant production while increasing antioxidant production in blood plasma. By reducing , DNG was able to alleviate inflammation and pain caused by inflammation in EM patients. In conclusion, the use of DNG in EM patients resulted in a decrease in concentration in the patient's plasma. Furthermore, this effect was enhanced by balancing oxidant/antioxidant levels, which may contribute to reducing inflammation associated with EM.

中文翻译：

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接受地诺孕素治疗的子宫内膜异位症患者血浆中 NLRP3 浓度、氧化剂和抗氧化剂

NOD 样受体 Pyrin 结构域 3 () 是一种胞质多蛋白复合物，可诱导炎症并受到孕酮的负向调节。先前的研究报道了子宫内膜异位症（EM）中活性氧（ROS）和孕激素抵抗的异常诱导。由于黄体酮调节 ROS 水平，从而调节炎症，因此我们的目标是研究地诺孕素 (DNG) 是否具有调节作用，以及 DNG 对 EM 患者血浆中炎症小体的调节是否会影响氧化剂和抗氧化标记物。从对照组和经历疼痛症状的 EM 患者中获取血浆样本，以测量氧化剂和抗氧化剂的水平。随后，这些患者接受口服 DNG 2 mg/天，为期六个月的药物治疗。六个月后，从患者身上采集血浆样本进行重新检查。研究结果表明，DNG 降低了浓度和氧化剂的产生，同时增加了血浆中抗氧化剂的产生。通过减少 ，DNG 能够减轻 EM 患者的炎症和炎症引起的疼痛。总之，EM 患者使用 DNG 导致患者血浆浓度降低。此外，平衡氧化剂/抗氧化剂水平可以增强这种效果，这可能有助于减少与 EM 相关的炎症。