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mRNA-1273 vaccinated inflammatory bowel disease patients receiving TNF inhibitors develop broad and robust SARS-CoV-2-specific CD8+ T cell responses
Journal of Autoimmunity ( IF 12.8 ) Pub Date : 2024-02-21 , DOI: 10.1016/j.jaut.2024.103175 Jet van den Dijssel , Mariël C. Duurland , Veronique AL. Konijn , Laura YL. Kummer , Ruth R. Hagen , Lisan H. Kuijper , Luuk Wieske , Koos PJ. van Dam , Eileen W. Stalman , Maurice Steenhuis , Dionne M. Geerdes , Juk Yee Mok , Angela HM. Kragten , Charlotte Menage , Lianne Koets , Barbera Veldhuisen , Niels JM. Verstegen , C Ellen van der Schoot , Wim JE. van Esch , Geert RAM. D'Haens , Mark Löwenberg , Adriaan G. Volkers , Theo Rispens , Taco W. Kuijpers , Filip Eftimov , Klaas PJM. van Gisbergen , S Marieke van Ham , Anja ten Brinke , Carolien E. van de Sandt , Renée CF. van Allaart , Adája E. Baars , Marcel W. Bekkenk , Frederike J. Bemelman , Laura Boekel , Amélie V. Bos , Angela L. Bosma , Bo Broens , Esther Brusse , Matthias H. Busch , Olvi Cristianawati , Pieter A. van Doorn , George Elias , Cécile ACM. van Els , Marit J. van Gils , H Stephan Goedee , Dirk Jan Hijnen , Marc L. Hilhorst , Barbara Horváth , Papay BP. Jallah , Rivka de Jongh , Elham S. Mirfazeli , Annelie H. Musters , Jim BD. Keijser , Zoé LE. van Kempen , Joep Killestein , Christine Kreher , Karina de Leeuw , Anneke J. van der Kooi , Lotte van Ouwerkerk , Pieter van Paassen , Virginia Palomares Cabeza , Agner R. Parra Sanchez , W. Ludo van der Pol , Nicoline F. Post , Joop Raaphorst , Annabel M. Ruiter , Abraham Rutgers , Corine RG. Schreurs , Phyllis I. Spuls , R Bart Takkenberg , Sander W. Tas , YK Onno Teng , Yosta Vegting , Jan JGM. Verschuuren , Alexandre E. Voskuyl , Jelle de Wit , Gerrit J. Wolbink , Diane van der Woude , Koos AH. Zwinderman
Journal of Autoimmunity ( IF 12.8 ) Pub Date : 2024-02-21 , DOI: 10.1016/j.jaut.2024.103175 Jet van den Dijssel , Mariël C. Duurland , Veronique AL. Konijn , Laura YL. Kummer , Ruth R. Hagen , Lisan H. Kuijper , Luuk Wieske , Koos PJ. van Dam , Eileen W. Stalman , Maurice Steenhuis , Dionne M. Geerdes , Juk Yee Mok , Angela HM. Kragten , Charlotte Menage , Lianne Koets , Barbera Veldhuisen , Niels JM. Verstegen , C Ellen van der Schoot , Wim JE. van Esch , Geert RAM. D'Haens , Mark Löwenberg , Adriaan G. Volkers , Theo Rispens , Taco W. Kuijpers , Filip Eftimov , Klaas PJM. van Gisbergen , S Marieke van Ham , Anja ten Brinke , Carolien E. van de Sandt , Renée CF. van Allaart , Adája E. Baars , Marcel W. Bekkenk , Frederike J. Bemelman , Laura Boekel , Amélie V. Bos , Angela L. Bosma , Bo Broens , Esther Brusse , Matthias H. Busch , Olvi Cristianawati , Pieter A. van Doorn , George Elias , Cécile ACM. van Els , Marit J. van Gils , H Stephan Goedee , Dirk Jan Hijnen , Marc L. Hilhorst , Barbara Horváth , Papay BP. Jallah , Rivka de Jongh , Elham S. Mirfazeli , Annelie H. Musters , Jim BD. Keijser , Zoé LE. van Kempen , Joep Killestein , Christine Kreher , Karina de Leeuw , Anneke J. van der Kooi , Lotte van Ouwerkerk , Pieter van Paassen , Virginia Palomares Cabeza , Agner R. Parra Sanchez , W. Ludo van der Pol , Nicoline F. Post , Joop Raaphorst , Annabel M. Ruiter , Abraham Rutgers , Corine RG. Schreurs , Phyllis I. Spuls , R Bart Takkenberg , Sander W. Tas , YK Onno Teng , Yosta Vegting , Jan JGM. Verschuuren , Alexandre E. Voskuyl , Jelle de Wit , Gerrit J. Wolbink , Diane van der Woude , Koos AH. Zwinderman
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SARS-CoV-2-specific CD8 T cells recognize conserved viral peptides and in the absence of cross-reactive antibodies form an important line of protection against emerging viral variants as they ameliorate disease severity. SARS-CoV-2 mRNA vaccines induce robust spike-specific antibody and T cell responses in healthy individuals, but their effectiveness in patients with chronic immune-mediated inflammatory disorders (IMIDs) is less well defined. These patients are often treated with systemic immunosuppressants, which may negatively affect vaccine-induced immunity. Indeed, TNF inhibitor (TNFi)-treated inflammatory bowel disease (IBD) patients display reduced ability to maintain SARS-CoV-2 antibody responses post-vaccination, yet the effects on CD8 T cells remain unclear.
中文翻译：
接受 TNF 抑制剂的 mRNA-1273 疫苗接种炎症性肠病患者会产生广泛而强大的 SARS-CoV-2 特异性 CD8+ T 细胞反应
SARS-CoV-2 特异性 CD8 T 细胞识别保守的病毒肽，在没有交叉反应抗体的情况下，形成针对新出现的病毒变体的重要保护线，因为它们可减轻疾病的严重程度。 SARS-CoV-2 mRNA 疫苗可在健康个体中诱导强烈的刺突特异性抗体和 T 细胞反应，但其对慢性免疫介导炎症性疾病 (IMID) 患者的有效性尚不明确。这些患者经常接受全身免疫抑制剂治疗，这可能会对疫苗诱导的免疫力产生负面影响。事实上，接受 TNF 抑制剂 (TNFi) 治疗的炎症性肠病 (IBD) 患者在接种疫苗后表现出维持 SARS-CoV-2 抗体反应的能力下降，但对 CD8 T 细胞的影响仍不清楚。
更新日期：2024-02-21
中文翻译：
接受 TNF 抑制剂的 mRNA-1273 疫苗接种炎症性肠病患者会产生广泛而强大的 SARS-CoV-2 特异性 CD8+ T 细胞反应
SARS-CoV-2 特异性 CD8 T 细胞识别保守的病毒肽，在没有交叉反应抗体的情况下，形成针对新出现的病毒变体的重要保护线，因为它们可减轻疾病的严重程度。 SARS-CoV-2 mRNA 疫苗可在健康个体中诱导强烈的刺突特异性抗体和 T 细胞反应，但其对慢性免疫介导炎症性疾病 (IMID) 患者的有效性尚不明确。这些患者经常接受全身免疫抑制剂治疗，这可能会对疫苗诱导的免疫力产生负面影响。事实上，接受 TNF 抑制剂 (TNFi) 治疗的炎症性肠病 (IBD) 患者在接种疫苗后表现出维持 SARS-CoV-2 抗体反应的能力下降，但对 CD8 T 细胞的影响仍不清楚。
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