Black women with breast cancer often present with more aggressive disease when compared to other races, contributing to an increased risk of cancer mortality. Despite this inequity, Black women remain severely underrepresented in breast cancer clinical trials. We aim to characterize factors that influence a woman's decision to enroll in a clinical trial, with the goal of identifying clinical interventions to aid in the recruitment of vulnerable groups. A cross-sectional, descriptive study was conducted using a questionnaire adapted from two pre-validated surveys investigating factors influencing clinical trial enrollment. The survey was administered to women with curable breast cancer during a single follow-up visit at four different sites within a university medical system where all patients are screened for clinical trial eligibility. Chi-square tests and Mann-Whitney U test were used to assess associations or differences between the populations. One hundred ninety-four out of 209 women completed the survey, giving a compliance rate of 93%. Twenty-six percent of women self-identified as Black, most women were located at community sites (67.1%), diagnosed with early-stage disease (I: 57.7%, II: 29.4%), and 81% of women had some collegiate level education. Black women were younger at diagnosis (p=0.005), less likely to be married (p=0.012), but more often lived with family members (p=0.003) and had a lower median income (p<0.001). On the survey, Black women were less likely to trust their care team (p=0.032), more likely to believe that research ultimately harms minorities (p<0.001) and had a stronger belief in God's will determining illness and wellness (p<0.001). Recurring themes of trust in the healthcare team, patient education and advancement of cancer treatments were discussed in the focus groups. Failure to offer clinical trials and mistrust in research institutions may pose the greatest hindrances to the enrollment of Black women on to clinical trials. Empowering women through education and fostering trustworthy relationships can encourage greater clinical trial participation.

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影响女性参加临床试验决定的社会心理因素——对如何提高黑人女性临床试验参加率的影响

与其他种族相比，患有乳腺癌的黑人女性通常会出现更具侵袭性的疾病，导致癌症死亡风险增加。尽管存在这种不平等，黑人女性在乳腺癌临床试验中的代表性仍然严重不足。我们的目标是描述影响女性参加临床试验决定的因素，目的是确定临床干预措施以帮助招募弱势群体。使用根据两项预先验证的调查改编的调查问卷进行了一项横断面描述性研究，调查影响临床试验入组的因素。这项调查是在大学医疗系统内的四个不同地点进行的一次随访中对患有可治愈乳腺癌的女性进行的，所有患者都经过临床试验资格筛查。卡方检验和曼惠特尼 U 检验用于评估人群之间的关联或差异。209 名女性中有 194 名完成了调查，符合率为 93%。26% 的女性自认是黑人，大多数女性位于社区场所（67.1%），被诊断患有早期疾病（I：57.7%，II：29.4%），81% 的女性有一些大学学历水平的教育。黑人女性诊断时年龄较小（p = 0.005），结婚的可能性较小（p = 0.012），但更经常与家庭成员住在一起（p = 0.003）并且收入中位数较低（p <0.001）。在调查中，黑人女性不太可能信任她们的护理团队 (p=0.032)，更有可能相信研究最终会伤害少数群体 (p<0.001)，并且更相信上帝的意志决定疾病和健康 (p<0.001) ）。焦点小组讨论了对医疗团队的信任、患者教育和癌症治疗进展等反复出现的主题。未能提供临床试验和对研究机构的不信任可能对黑人女性参加临床试验构成最大障碍。通过教育赋予妇女权力并培养值得信赖的关系可以鼓励更多的临床试验参与。