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Survival after cryptococcosis in Germany: A retrospective multicenter cohort study of patients diagnosed between 2004 and 2021
International Journal of Medical Microbiology ( IF 4.1 ) Pub Date : 2024-02-16 , DOI: 10.1016/j.ijmm.2024.151614
Johanna Kessel , Anna-Catharina Rossaert , Tilman Lingscheid , Jan Grothe , Thomas Harrer , Christoph Wyen , Daniela Tominski , T. Bollinger , Anna Katharina Kehr , Sven Kalbitz , Christian Hoffmann , Oliver Cornely , Uwe Koppe , Christoph Stephan , Volker Rickerts

Cryptococcosis is the most prevalent fungal infection of the central nervous system worldwide. We performed a retrospective multicenter cohort study to gain insights into the epidemiology of cryptococcosis in Germany. We describe the use of diagnostic tests, clinical management and patient outcome. We included 64 patients with underlying HIV infection (55%) or other predispositions. Molecular typing by MLST documented 20 individual sequence types among 42 typed isolates. A fatal outcome was documented in 14% of patients in the first two months after diagnosis.

中文翻译:

德国隐球菌病后的生存率:对 2004 年至 2021 年诊断的患者进行的回顾性多中心队列研究

隐球菌病是全世界最常见的中枢神经系统真菌感染。我们进行了一项回顾性多中心队列研究,以深入了解德国隐球菌病的流行病学。我们描述了诊断测试的使用、临床管理和患者结果。我们纳入了 64 名患有潜在 HIV 感染 (55%) 或其他易感性的患者。 MLST 的分子分型记录了 42 个分型分离株中的 20 个单独的序列类型。据记录,14% 的患者在诊断后的头两个月内出现致命结果。
更新日期:2024-02-16
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