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Efficacy of Lactobacillus taiwanensis S29 and Lactiplantibacillus plantarum S27 against tapeworm infection in Swiss Albino rats
Experimental Parasitology ( IF 2.1 ) Pub Date : 2024-02-07 , DOI: 10.1016/j.exppara.2024.108715 Sudeshna Mandal , Chandrani Mondal , Sinchan Ghosh , Samiparna Saha , Mou Singha Ray , Larisha M. Lyndem
Experimental Parasitology ( IF 2.1 ) Pub Date : 2024-02-07 , DOI: 10.1016/j.exppara.2024.108715 Sudeshna Mandal , Chandrani Mondal , Sinchan Ghosh , Samiparna Saha , Mou Singha Ray , Larisha M. Lyndem
a zoonotic tapeworm infection in human remains an important cestode model for anthelmintic study as it display common clinical symptoms like other adult human tapeworms during heavy infestation. The use of as a probiotic is an alternative to drugs which have increased in research and usage considerably during the last decade. The present study aims to determine the anthelmintic efficacy of two probiotics, strain S29 and strain S27 against in infected rat. Four groups of animals, each with six numbers were randomly chosen as the negative control (Group I), positive control (infected) (Group II) and the infected treated with two probiotics Group III and Group IV respectively. Another four groups (Group V-VIII) were selected and further subdivided into four sub-groups to investigate the development of larvae to adult during probiotics treatment. Worm burden, egg per gram were determined after treatment with these two probiotics. Furthermore, hematological assays and levels of biochemical markers were estimated, tissue damage was assayed through histological study and intestinal mitochondria detection was done. Worm sustainability reduced about 70–90% and EPG count decreased by 81–94% in probiotics treated groups. A significant level of unsuccessful establishment of larvae was observed in the developmental phase. Improvement in hematological parameter along with some biochemical parameters in the host were significantly observed after treatment with probiotics. The architecture damaged caused in the intestine and mitochondria density due to parasite infection improved significantly as that of control after probiotics treatment.
更新日期：2024-02-07
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