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Identification of benzothiazole derived monosaccharides as potent, selective, and orally bioavailable inhibitors of human and mouse galectin-3; a rare example of using a S···O binding interaction for drug design
Bioorganic & Medicinal Chemistry ( IF 3.5 ) Pub Date : 2024-02-11 , DOI: 10.1016/j.bmc.2024.117638
Chunjian Liu , Wei Wang , Jianxin Feng , Brett Beno , Thiruvenkadam Raja , Jacob Swidorski , Raju K. V. L. P. Manepalli , Muthalagu Vetrichelvan , Prasada Rao Jalagam , Satheesh K. Nair , Anuradha Gupta , Manoranjan Panda , Kaushik Ghosh , Jinal Kaushikkumar Shukla , Harinath Sale , Devang Shah , Shashyendra Singh Gautam , Dipal Patel , Arvind Mathur , Bruce A. Ellsworth , Dong Cheng , Alicia Regueiro-Ren

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中文翻译:

鉴定苯并噻唑衍生的单糖作为人和小鼠半乳糖凝集素 3 的有效、选择性和口服生物利用度抑制剂;使用 S·O 结合相互作用进行药物设计的罕见例子

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更新日期:2024-02-11
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