The tendency to use less-invasive laser-based methods with far more obvious effectiveness has been taken into consideration today for improvement of burning scars. The present study thus aimed to assess the efficacy of two laser-based techniques including pulsed dye laser (PDL) and ablative fractional CO2 laser (AFCL) and its combination on improving different aspects of burning scars regardless of the types of scar as hypertrophic or keloid scars. This randomized single-blinded clinical trial was performed on patients suffering hypertrophic or keloid burning scars. The patients were randomly assigned into three groups scheduling for treatment with PDL alone, AFCL alone, or its combination. All patients were visited before and 40 days after the last treatment session, and their scars were assessed. In all groups, significant improvement was revealed in the Vancouver scar scale (VSS) score, the color of scar, vascular bed in the scar, the and height of scar and its pliability; however, the improvement in each item was more highlighted in the group receiving a combination therapy with PDL and AFCL techniques. In this regard, the highest improvement was found in vascular bed and pliability in the combination therapy group as compared to other groups. Although the superiority of the combined group was not statistically significant, due to the high percentage of improvement in total VSS and most of its indicators, it can be clinically significant. The efficacy of the treatment protocols was different considering subgroups of mature and immature scars (less than 1 year), so that more improvement in pliability of scar, vascularity, and color of scar was found in the group scheduling for PDL + AFCL as compared to those who were treated with PDL alone in immature scar group but not in mature scar group. Combined treatment can be much more effective in improving the appearance and pathological characteristics of scars than each individual treatment. This effectiveness can be seen mainly in immature scars.

如今，为了改善烧伤疤痕，人们已经考虑使用具有更明显效果的微创激光方法。因此，本研究旨在评估两种基于激光的技术（包括脉冲染料激光（PDL）和烧蚀点阵CO2激光（AFCL））及其组合在改善烧伤疤痕不同方面的功效，无论疤痕类型为肥厚性还是疤痕疙瘩伤疤。这项随机单盲临床试验是针对患有肥厚性或疤痕疙瘩烧伤疤痕的患者进行的。患者被随机分为三组，分别接受单独 PDL、单独 AFCL 或其组合治疗。在最后一次治疗之前和之后 40 天对所有患者进行了探访，并对他们的疤痕进行了评估。所有组中，温哥华疤痕量表（VSS）评分、疤痕颜色、疤痕血管床、疤痕高度和柔韧性均有显着改善；然而，在接受 PDL 和 AFCL 技术联合治疗的组中，每一项的改善更为突出。在这方面，与其他组相比，联合治疗组的血管床和柔韧性得到了最大的改善。尽管联合治疗组的优越性并不具有统计学意义，但由于总 VSS 及其大部分指标的改善百分比较高，因此具有临床意义。考虑到成熟和未成熟疤痕（小于 1 年）的亚组，治疗方案的功效有所不同，因此与 PDL + AFCL 组相比，在疤痕柔韧性、血管分布和疤痕颜色方面发现了更多改善未成熟疤痕组仅接受PDL治疗，成熟疤痕组未接受PDL治疗。联合治疗在改善疤痕的外观和病理特征方面比单独治疗更有效。这种效果主要体现在未成熟的疤痕上。