We performed a longitudinal shotgun metagenomic investigation of the plaque microbiome associated with peri-implant diseases in a cohort of 91 subjects with 320 quality-controlled metagenomes. Through recently improved taxonomic profiling methods, we identified the most discriminative species between healthy and diseased subjects at baseline, evaluated their change over time, and provided evidence that clinical treatment had a positive effect on plaque microbiome composition in patients affected by mucositis and peri-implantitis.

中文翻译：

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有利的龈下菌斑微生物组变化与种植体周围疾病的临床治疗相关

我们对 91 名受试者和 320 个质量控制宏基因组的队列中与种植体周围疾病相关的菌斑微生物组进行了纵向鸟枪法宏基因组研究。通过最近改进的分类学分析方法，我们在基线时确定了健康受试者和患病受试者之间最具区别性的物种，评估了它们随时间的变化，并提供了临床治疗对粘膜炎和种植体周围炎患者的菌斑微生物组组成产生积极影响的证据。