Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability,mAbs

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Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability
mAbs ( IF 5.3 ) Pub Date : 2024-02-14 , DOI: 10.1080/19420862.2024.2309685
Wei-Ching Liang ₁ , Hongkang Xi ₁ , Dawei Sun ₂ , Luigi D’Ascenzo ₂ , Jonathan Zarzar ₃ , Nicole Stephens ₃ , Ryan Cook ₄ , Yinyin Li ₄ , Zhengmao Ye _{4,

5} , Marissa Matsumoto _{2,

6} , Jian Payandeh _{2,

7} , Matthieu Masureel ₂ , Yan Wu ₁

Affiliation

Rabbits produce robust antibody responses and have unique features in their antibody repertoire that make them an attractive alternative to rodents for in vivo discovery. However, the frequent occu...

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