Cancer-associated cachexia (CAC) is a debilitating syndrome associated with poor quality of life and reduced life expectancy of cancer patients. CAC is characterized by unintended body weight reduction due to muscle and adipose tissue loss. A major hallmark of CAC is systemic inflammation. Several non-steroidal anti-inflammatory drugs (NSAIDs) have been suggested for CAC treatment, yet no single medication has proven reliable. R-ketorolac (RK) is the R-enantiomer of a commonly used NSAID. The effect of RK on CAC has not yet been evaluated.

中文翻译：

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R-酮咯酸可改善癌症相关的恶病质并延长荷瘤小鼠的生存期

癌症相关恶病质（CAC）是一种使人衰弱的综合征，与癌症患者的生活质量差和预期寿命缩短有关。 CAC 的特点是由于肌肉和脂肪组织损失而导致体重意外减轻。 CAC 的一个主要特征是全身炎症。几种非甾体抗炎药 (NSAID) 已被建议用于 CAC 治疗，但没有一种药物被证明是可靠的。 R-酮咯酸 (RK) 是常用 NSAID 的 R-对映体。 RK 对 CAC 的影响尚未评估。