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Electrostatic properties of human germlines and biodistribution of small biologics
mAbs ( IF 5.3 ) Pub Date : 2024-02-09 , DOI: 10.1080/19420862.2024.2311991
Leticia Maria De Souza Cordeiro 1 , Kelley Christine Atkinson 1 , Argin Aivazian 1 , Patrick Frank Joyce 2 , Fang Jia 1 , Alessandro Mascioni 1
Affiliation  

Off-target biodistribution of biologics bears important toxicological consequences. Antibody fragments intended for use as vectors of cytotoxic payloads (e.g. antibody-drug conjugates, radiotherapy...

中文翻译:

人类种系的静电特性和小型生物制剂的生物分布

生物制剂的脱靶生物分布会产生重要的毒理学后果。抗体片段旨在用作细胞毒性有效负载的载体(例如抗体-药物缀合物、放射治疗......
更新日期:2024-02-13
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