Summary: Mutant p53 proteins are often highly expressed in human cancers and have been thought to have oncogenic driver gain-of-function (GOF) properties. Wang and colleagues show, surprisingly, that this is not the case because removing the TP53-mutant gene from human and mouse cancer cells using CRISPR technology has no effect on cancer cell growth in vitro or in vivo. See related article by Wang et al., p. 362 (10) .

中文翻译：

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聚光灯下的突变 p53 功能获得：我们是否患有 GOF 错觉？

摘要：突变的 p53 蛋白通常在人类癌症中高表达，并被认为具有致癌驱动功能获得（GOF）特性。令人惊讶的是，Wang 及其同事发现事实并非如此，因为使用 CRISPR 技术从人类和小鼠癌细胞中去除 TP53 突变基因对体外或体内癌细胞的生长没有影响。参见 Wang 等人的相关文章，第 17 页。 362（10）。