Chronic hypoxia and skeletal muscle atrophy commonly coexist in patients with COPD and CHF, yet the underlying physio-pathological mechanisms remain elusive. Muscle regeneration, driven by muscle stem cells (MuSCs), holds therapeutic potential for mitigating muscle atrophy. This study endeavours to investigate the influence of chronic hypoxia on muscle regeneration, unravel key molecular mechanisms, and explore potential therapeutic interventions.

中文翻译：

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慢性缺氧通过 HIF-2α 稳定作用损害骨骼肌修复

慢性缺氧和骨骼肌萎缩通常在慢性阻塞性肺病和慢性心力衰竭患者中同时存在，但潜在的生理病理机制仍然难以捉摸。由肌肉干细胞 (MuSC) 驱动的肌肉再生具有减轻肌肉萎缩的治疗潜力。本研究致力于研究慢性缺氧对肌肉再生的影响，揭示关键分子机制，并探索潜在的治疗干预措施。