Numbers of infections with are among the top three sexually transmitted infections (STI) worldwide. In addition, the emergence and spread of antimicrobial resistance (AMR) in pose an important public-health issue. The integration of genomic, phenotypic and epidemiological data to monitor fosters our understanding of the emergence and spread of AMR in and helps to inform therapy guidelines and intervention strategies. Thus, the Gonococcal resistance surveillance (Go-Surv-AMR) was implemented at the Robert Koch Institute in Germany in 2021 to obtain molecular, phenotypic and epidemiological data on isolated in Germany. Here, we describe the structure and aims of Go-Surv-AMR. Furthermore, we point out future directions of Go-Surv-AMR to improve the integrated genomic surveillance of . In this context we discuss current and prospective sequencing approaches and the information derived from their application. Moreover, we highlight the importance of combining phenotypic and WGS data to monitor the evolution of AMR in in Germany. The implementation and constant development of techniques and tools to improve the genomic surveillance of will be important in coming years.

中文翻译：

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德国淋病奈瑟菌抗菌药物耐药性的综合分子、表型和流行病学监测

感染人数位居全球性传播感染（STI）前三位。此外，抗菌素耐药性（AMR）的出现和传播构成了重要的公共卫生问题。整合基因组、表型和流行病学数据进行监测，有助于我们了解抗菌素耐药性的出现和传播，并有助于为治疗指南和干预策略提供信息。因此，德国罗伯特·科赫研究所于2021年实施了淋球菌耐药性监测（Go-Surv-AMR），以获得德国分离株的分子、表型和流行病学数据。在这里，我们描述了 Go-Surv-AMR 的结构和目标。此外，我们指出了 Go-Surv-AMR 的未来方向，以改善 的综合基因组监测。在此背景下，我们讨论当前和未来的测序方法以及从其应用中获得的信息。此外，我们强调了结合表型和全基因组测序数据来监测德国 AMR 演变的重要性。未来几年，实施和不断开发改善基因组监测的技术和工具将非常重要。