Objective. This study investigated the prognostic factors of anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis (MDA5-DM). Methods. This study analysed 34 MDA5-DM cases (20 and 14 in the survival and death groups, respectively) encountered at Kurume University between 2008 and 2021. The clinical, physiological, and computed tomography findings, pulmonary function, and serological results were retrospectively evaluated for each MDA5-DM case during the first visit and throughout the next 12 weeks. Results. In the death group, the mean age of patients was higher (47.6 vs. 61.8 years), while the duration from symptom onset to consultation was shorter (110 vs. 34.9 days). During the first visit, the death group demonstrated a significantly higher serum C-reactive protein (CRP) level (0.52 vs. 1.99) and a significantly lower albumin level (3.23 vs. 2.63) than the survival group; this persisted throughout the next 12 weeks. Poor prognosis was associated with CRP and albumin levels above 0.19 mg/dL and below 2.3 g/dL, respectively, 4 weeks after starting treatment. Conclusion. Four weeks after beginning treatment, serum CRP and albumin levels of patients with MDA5-DM can be used to evaluate treatment response and predict prognosis.

中文翻译：

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抗黑色素瘤分化相关基因5抗体阳性皮肌炎预后因素的检查

客观的。本研究探讨了抗黑色素瘤分化相关基因5抗体阳性皮肌炎（MDA5-DM）的预后因素。方法。本研究分析了 2008 年至 2021 年间在久留米大学遇到的 34 例 MDA5-DM 病例（生存组和死亡组分别为 20 例和 14 例）。回顾性评估了临床、生理和计算机断层扫描结果、肺功能和血清学结果每个 MDA5-DM 病例在第一次就诊期间以及接下来的 12 周内。结果。在死亡组中，患者的平均年龄较高（47.6岁对61.8岁），而从症状出现到就诊的时间较短（110天对34.9天）。在第一次就诊期间，死亡组的血清 C 反应蛋白 (CRP) 水平显着高于存活组（0.52 vs. 1.99），白蛋白水平显着低于存活组（3.23 vs. 2.63）；这种情况在接下来的 12 周内持续存在。不良预后与开始治疗 4 周后 CRP 和白蛋白水平分别高于 0.19 mg/dL 和低于 2.3 g/dL 相关。结论。开始治疗4周后，MDA5-DM患者的血清CRP和白蛋白水平可用于评估治疗反应和预测预后。