In this work, we report an effective, one-pot syntheses of benzo[4,5]imidazo[1,2-a]pyrimidine and pyrano[4,3-b]pyran derivatives using L-glutamine functionalized nanoparticles (Fe₃O₄@SiO₂@L-glutamine NPs) under microwave irradiation. The organo-nanocatalyst underwent characterization through diverse techniques, including FT-IR, p-XRD, SEM, TEM, EDX, XPS, TGA, and VSM. Microwave irradiation and multicomponent reactions synergistically yield excellent product yields (≈80%–95%) in shorter reaction times (≈6–15 min) with a broader substrate scope. The organo-nanocatalyst displays notable catalytic efficacy, evidenced by high turnover numbers (TON) and turnover frequencies (TOF) across syntheses. This innovative protocol showcases exceptional efficiency, cost-effectiveness, and environmental friendliness, with advantages like minimal reaction conditions, easy catalytic recovery, recyclability, operational simplicity, and the use of eco-friendly solvents.

中文翻译：

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L-谷氨酰胺功能化磁性纳米粒子在水:乙醇混合物中催化微波辅助合成苯并[4,5]咪唑并[1,2-a]嘧啶和吡喃并[4,3-b]吡喃

在这项工作中，我们报告了使用L-谷氨酰胺功能化纳米颗粒（Fe ₃ O ₄ @SiO ₂ @L-谷氨酰胺纳米粒子）在微波照射下。有机纳米催化剂通过多种技术进行表征，包括 FT-IR、p-XRD、SEM、TEM、EDX、XPS、TGA 和 VSM。微波辐射和多组分反应协同作用，在更短的反应时间（约 6–15 分钟）和更广泛的底物范围内产生优异的产物收率（约 80%–95%）。有机纳米催化剂表现出显着的催化功效，合成过程中的高周转数 (TON) 和周转频率 (TOF) 证明了这一点。这种创新的方案展示了卓越的效率、成本效益和环境友好性，具有反应条件最少、易于催化回收、可回收性、操作简单性和使用环保溶剂等优点。