A series of gallic acid derivatives containing acyl thiourea phenol were designed and synthesized with gallic acid as a raw material, and their antibacterial activities were evaluated: the synthesized acyl thiourea phenol derivatives of gallic acid had certain anti-Vibrio activity at 1 mg/mL; compounds 4a and 4c showed good inhibitory activity against Vibrio harveyi, MIC was 0.0156 mg/mL; compound 4f also showed certain anti-Vibrio cholerae activity, MIC was 0.0313 mg/mL; compound 4g showed anti-Vibrio parahaemolyticus activity, MIC was 0.0156 mg/mL; this series of compounds has poor inhibitory activity against Vibrio vulnificus. Only compounds 4a, 4c, 4e, 4g, and 4j have weak inhibitory activity against Vibrio vulnificus, with MIC of 0.125 mg/mL.

以没食子酸为原料，设计合成了一系列含有酰基硫脲酚的没食子酸衍生物，并对其抗菌活性进行了评价：合成的没食子酸酰基硫脲酚衍生物在1 mg/mL下具有一定的抗弧菌活性；化合物4a和4c对哈维弧菌具有良好的抑制活性，MIC为0.0156 mg/mL；化合物4f也表现出一定的抗霍乱弧菌活性，MIC为0.0313 mg/mL；化合物4g具有抗副溶血弧菌活性，MIC为0.0156mg/mL；该系列化合物对创伤弧菌的抑制活性较差。仅化合物4a、4c、4e、4g和4j对创伤弧菌有弱抑制活性，MIC为0.125 mg/mL。