Multidrug resistance protein 7 (MRP7), also known as ATP-binding cassette (ABC) transporter subfamily C10 (ABCC10), is an ABC transporter that was first identified in 2001. ABCC10/MRP7 is a 171 kDa protein located on the basolateral membrane of cells. ABCC10/MRP7 consists of three transmembrane domains and two nucleotide binding domains. It mediates multidrug resistance of tumor cells to a variety of anticancer drugs by increasing drug efflux and results in reducing intracellular drug accumulation. The transport substrates of ABCC10/MRP7 include antineoplastic drugs such as taxanes, vinca alkaloids, and epothilone B, as well as endobiotics such as leukotriene C4 (LTC) and estradiol 17 β-D-glucuronide. A variety of ABCC10/MRP7 inhibitors, including cepharanthine, imatinib, erlotinib, tariquidar, and sildenafil, can reverse ABCC10/MRP7-mediated MDR. Additionally, the presence or absence of ABCC10/MRP7 is also closely related to renal tubular dysfunction, obesity, and other diseases. In this review, we discuss: 1) Structure and functions of ABCC10/MRP7; 2) Known substrates and inhibitors of ABCC10/MRP7 and their potential therapeutic applications in cancer; and 3) Role of ABCC10/MRP7 in non-cancerous diseases.

中文翻译：

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ABCC10/MRP7 在抗癌耐药性及其他方面的作用

多药耐药蛋白 7 (MRP7)，也称为 ATP 结合盒 (ABC) 转运蛋白亚家族 C10 (ABCC10)，是 2001 年首次发现的 ABC 转运蛋白。ABCC10/MRP7 是一种 171 kDa 的蛋白，位于细胞。ABCC10/MRP7 由三个跨膜结构域和两个核苷酸结合结构域组成。它通过增加药物外流介导肿瘤细胞对多种抗癌药物的多药耐药性，并减少细胞内药物积累。ABCC10/MRP7的转运底物包括抗肿瘤药物如紫杉烷类、长春花生物碱和埃博霉素B，以及内生素如白三烯C4(LTC)和雌二醇17β-D-葡萄糖醛酸苷。多种 ABCC10/MRP7 抑制剂，包括千金藤素、伊马替尼、厄洛替尼、塔利奎达和西地那非，可以逆转 ABCC10/MRP7 介导的多药耐药。此外，ABCC10/MRP7的存在与否也与肾小管功能障碍、肥胖等疾病密切相关。在这篇综述中，我们讨论：1）ABCC10/MRP7的结构和功能；2）ABCC10/MRP7的已知底物和抑制剂及其在癌症中的潜在治疗应用；3) ABCC10/MRP7 在非癌症疾病中的作用。