Previous studies have shown that maternal resveratrol improved growth performance and altered the microbial composition of suckling piglets under hot summer conditions. However, it remains unclear how maternal resveratrol improves growth performance of suckling piglets under high summer temperatures. A total of 20 sows (landrace × large white; three parity) were randomly assigned to 2 groups (with or without 300 mg/kg resveratrol) from d 75 of gestation to d 21 of lactation in a high temperature environment (from 27 to 30 °C). The results showed that maternal resveratrol supplementation increased total daily weight gain of piglets under hot summer conditions, which is consistent with previous studies. Furthermore, we found that maternal resveratrol improved the intestinal morphology and intestinal epithelial proliferation in suckling piglets. Dietary resveratrol supplementation affected the characteristics of exosome-derived microRNAs (miRNAs) in sow colostrum, as well as the genes targeted by differentially produced miRNAs. MiRNAs are concentrated in the tight junction pathway. As a result, the expression of intestinal tight junction proteins was increased in suckling piglets (P < 0.05). Notably, maternal resveratrol increased the intestinal secretory immunoglobulin A (sIgA) levels of suckling piglets via colostrum immunoglobins (P < 0.05), which could increase the abundance of beneficial microbiota to further increase the concentration of short chain fatty acids (SCFA) in suckling piglets' intestine (P < 0.05). Finally, our correlation analysis further demonstrated the positive associations between significantly differential intestinal microbiota, intestinal sIgA production and SCFA concentrations, as well as the positive relation between total daily weight gain and intestinal health of suckling piglets. Taken together, our findings suggested that maternal resveratrol could promote intestinal health to improve piglet growth under high summer temperatures, which might be associated with the immunoglobin and exosome-derived miRNAs in sows’ colostrum.

先前的研究表明，母体白藜芦醇可以改善炎热夏季条件下哺乳仔猪的生长性能并改变微生物组成。然而，目前尚不清楚母体白藜芦醇如何在夏季高温下改善哺乳仔猪的生长性能。妊娠第 75 天至泌乳第 21 天，在高温环境下（27～30℃），将 20 头母猪（长白×大白；三胎）随机分为 2 组（加或不加 300 mg/kg 白藜芦醇）。 ℃）。结果表明，在炎热的夏季条件下，母体补充白藜芦醇增加了仔猪的日总增重，这与之前的研究一致。此外，我们发现母体白藜芦醇改善了哺乳仔猪的肠道形态和肠上皮增殖。日粮中添加白藜芦醇会影响母猪初乳中外泌体衍生的 microRNA (miRNA) 的特征，以及差异产生的 miRNA 所针对的基因。miRNA 集中在紧密连接通路中。结果，哺乳仔猪肠道紧密连接蛋白的表达增加（P < 0.05）。值得注意的是，母体白藜芦醇通过初乳免疫球蛋白增加了哺乳仔猪肠道分泌性免疫球蛋白A（sIgA）水平（P < 0.05），这可以增加有益微生物群的丰度，从而进一步提高哺乳仔猪中短链脂肪酸（SCFA）的浓度'肠（P <0.05）。最后，我们的相关性分析进一步证明了显着差异的肠道菌群、肠道 sIgA 产量和 SCFA 浓度之间的正相关性，以及哺乳仔猪日总增重与肠道健康之间的正相关性。总而言之，我们的研究结果表明，母体白藜芦醇可以促进肠道健康，从而改善夏季高温下仔猪的生长，这可能与母猪初乳中的免疫球蛋白和外泌体衍生的 miRNA 有关。