Stereoselective homoaldol reactions remain a prominent challenge with limited success. In this work, we describe a photoredox/Cr/Co triple-catalyzed regio- and stereoselective homoaldol reaction using internal 1,3-dienes as a homoenolate equivalent. This protocol obviates the need for strong bases and stoichiometric chiral reagents, characteristic of classical approaches. Robustness and practicality are demonstrated via application in late-stage modification and the formal synthesis of bioactive compounds and natural products.

中文翻译：

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通过光氧化还原/Cr/Co三重催化实现立体选择性高羟醛反应的模块化方法

立体选择性高羟醛反应仍然是一个突出的挑战，但成功有限。在这项工作中，我们描述了使用内部 1,3-二烯作为高烯醇等价物的光氧化还原/Cr/Co 三重催化区域和立体选择性高醛醇反应。该方案消除了对强碱和化学计量手性试剂的需求，这是经典方法的特征。通过在生物活性化合物和天然产物的后期修饰和正式合成中的应用证明了鲁棒性和实用性。