Secondary hypertension is often caused by activation of complex multi-organ endocrine systems, while renin activity indicated by angiotensins (Angs), aldosterone (ALD) and cortisol (COR) in such systems are generally accepted as its diagnostic markers. As antibody-based methods cannot offer comparable quantification for these biomarkers, a liquid chromatography (LC)–tandem mass spectrometry (MS/MS)-based approach was developed to quantify them simultaneously and accurately.

中文翻译：

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通过磁固相萃取和液相色谱-串联质谱联用同时定量继发性高血压的生物标志物组

继发性高血压往往是由复杂的多器官内分泌系统激活引起的，而这些系统中血管紧张素（Angs）、醛固酮（ALD）和皮质醇（COR）所指示的肾素活性被普遍认为是其诊断标志物。由于基于抗体的方法无法对这些生物标志物进行可比较的定量，因此开发了一种基于液相色谱 (LC) - 串联质谱 (MS/MS) 的方法来同时准确地定量它们。