Social isolation is a chronic mild stressor and a significant risk factor for mental health disorders. Herein we explored the impact of social isolation on depression- and anxiety-like behaviours, as well as spatial memory impairments, in middle-aged male mice compared to post-weaning mice. We aimed to quantify and correlate social isolation-induced behaviour discrepancies with changes in hippocampal glial cell reactivity and pro-inflammatory cytokine levels.

中文翻译：

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社会隔离对小鼠的年龄相关影响：年轻与中年

社会隔离是一种慢性轻度压力​​源，也是精神健康障碍的重要危险因素。在此，我们探讨了中年雄性小鼠与断奶后小鼠相比，社会隔离对抑郁和焦虑样行为以及空间记忆障碍的影响。我们的目的是量化社会隔离引起的行为差异与海马胶质细胞反应性和促炎细胞因子水平的变化并将其关联起来。