Epac2 activation mediates glucagon-induced glucogenesis in primary rat hepatocytes,Journal of Diabetes Investigation

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Epac2 activation mediates glucagon-induced glucogenesis in primary rat hepatocytes
Journal of Diabetes Investigation ( IF 3.1 ) Pub Date : 2024-01-19 , DOI: 10.1111/jdi.14142
Yusuke Shiozaki-Takagi _{1,

2} , Nobuaki Ozaki _{1,

3} , Yukiyasu Toyoda ₂

Affiliation

Glucagon plays an essential role in hepatic glucogenesis by enhancing glycogen breakdown, inducing gluconeogenesis, and suppressing glycogenesis. Moreover, glucagon increases cyclic adenosine monophosphate (cAMP) levels, thereby activating protein kinase A (PKA) and cAMP guanine nucleotide exchange factor (also known as Epac). Although the function of PKA in the liver has been studied extensively, the function of hepatic Epac is poorly understood. The aim of this study was to elucidate the role of Epac in mediating the action of glucagon on the hepatocytes.

中文翻译：

Epac2激活介导原代大鼠肝细胞中胰高血糖素诱导的糖生成

胰高血糖素通过增强糖原分解、诱导糖异生和抑制糖原生成，在肝糖生成中发挥重要作用。此外，胰高血糖素会增加环磷酸腺苷 (cAMP) 水平，从而激活蛋白激酶 A (PKA) 和 cAMP 鸟嘌呤核苷酸交换因子（也称为 Epac）。尽管 PKA 在肝脏中的功能已被广泛研究，但对肝脏 Epac 的功能知之甚少。本研究的目的是阐明 Epac 在介导胰高血糖素对肝细胞的作用中的作用。

更新日期：2024-01-19

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