Four cytotoxic heptacyclic caged-xanthones [gambogefic acids B–E (1–4)], a cytotoxic hexacyclic caged-xanthone [garcilatelic acid (5)], and four biphenyl derivatives [garcilatelibiphenyls A–D (6–9)] were newly isolated in a phytochemical study of a 50% MeOH/CH₂Cl₂ extract of Garcinia lateriflora (Clusiaceae). The isolated compounds were evaluated for antiproliferative activity against five human tumor cell lines including a vincristine-resistant line. The new caged-xanthones displayed potent activity with IC₅₀ values from 0.5 to 6.7 μM against all tested tumor cell lines.

中文翻译：

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从热带植物藤黄中分离出的笼状氧杂蒽酮和联苯

新发现了四种细胞毒性七环笼状呫吨酮 [gambogefic Acids B–E ( 1 – 4 )]、一种细胞毒性六环笼状呫吨酮 [garciatelic Acid ( 5 )] 和四种联苯衍生物 [garciatelibiphens A–D ( 6 – 9 )]在藤黄果（藤黄科）的 50% MeOH/CH ₂ Cl ₂提取物的植物化学研究中分离出来。评估了分离的化合物对五种人类肿瘤细胞系（包括长春新碱抗性细胞系）的抗增殖活性。新的笼状氧杂蒽酮对所有测试的肿瘤细胞系均表现出有效的活性，IC ₅₀值为 0.5 至 6.7 μM。