As cannabidiol (CBD) is not considered to be a drug and because of its potential health claims, it is an interesting compound that is often found in cosmetics. However, the safety of CBD, as well as the presence of trace amounts of other phytocannabinoids, including the psychoactive substance ∆⁹-tetrahydrocannabinol (THC), is still being debated. A robust analytical technique capable of analysing cosmetic products and determining their phytocannabinoid content will be crucial in assessing the safety of these products. This systematic review aims to highlight the current analytical tools that could be used to analyse phytocannabinoids in cosmetics. The ideal method would be able to analyse high levels of CBD in combination with trace levels of THC and their acids. The method should provide good recoveries and accuracies in a variety of matrices while providing information on up-coming phytocannabinoids such as cannabichromene (CBC), cannabigerol (CBG) and cannabinol (CBN). The systematic review approach was based on the Preferred Reporting Items for Systematic review and Meta-Analyses method. The research focused on studies published from January 2010 to December 2022 in PubMed and Scopus. A total of 15 datasets met the inclusion and exclusion criteria and were tabulated to allow easy comparison. Although some of the reviewed methods can handle multiple matrices and provide satisfactory recoveries, this review process did not identify an ideal method. The most suitable methods either could not quantify phytocannabinoid acids or were not sensitive enough to quantify trace levels of psychoactive phytocannabinoids.

中文翻译：

---

能够分析化妆品中植物大麻素的分析方法的系统综述

由于大麻二酚 (CBD) 不被认为是一种药物，并且由于其潜在的健康声明，因此它是一种有趣的化合物，经常出现在化妆品中。然而，CBD 的安全性以及微量其他植物大麻素的存在，包括精神活性物质 Δ ⁹ -四氢大麻酚 (THC)，仍然存在争议。能够分析化妆品并确定其植物大麻素含量的强大分析技术对于评估这些产品的安全性至关重要。本系统综述旨在强调当前可用于分析化妆品中植物大麻素的分析工具。理想的方法是能够分析高含量的 CBD 以及痕量的 THC 及其酸。该方法应在各种基质中提供良好的回收率和准确度，同时提供有关即将推出的植物大麻素的信息，例如大麻环烯 (CBC)、大麻醇 (CBG) 和大麻酚 (CBN)。系统评价方法基于系统评价的首选报告项目和荟萃分析方法。该研究重点关注 2010 年 1 月至 2022 年 12 月在 PubMed 和 Scopus 上发表的研究。共有 15 个数据集符合纳入和排除标准，并制成表格以便于比较。尽管一些审查的方法可以处理多个基质并提供令人满意的回收率，但该审查过程并未确定理想的方法。最合适的方法要么无法量化植物大麻素酸，要么不够灵敏，无法量化微量水平的精神活性植物大麻素。