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Bridging Reduced Grip Strength and Altered Executive Function: Specific Brain White Matter Structural Changes in Patients with Alzheimer’s Disease
Clinical Interventions in Aging ( IF 3.6 ) Pub Date : 2024-01-16 , DOI: 10.2147/cia.s438782 Shan-Wen Liu , Xiao-Ting Ma , Shuai Yu , Xiao-Fen Weng , Meng Li , Jiangtao Zhu , Chun-Feng Liu , Hua Hu
Clinical Interventions in Aging ( IF 3.6 ) Pub Date : 2024-01-16 , DOI: 10.2147/cia.s438782 Shan-Wen Liu , Xiao-Ting Ma , Shuai Yu , Xiao-Fen Weng , Meng Li , Jiangtao Zhu , Chun-Feng Liu , Hua Hu
Objective: To investigate the correlation between specific fiber tracts and grip strength and cognitive function in patients with Alzheimer’s disease (AD) by fixel-based analysis (FBA).
Methods: AD patients were divided into AD with low grip strength (AD-LGS, n=29) and AD without low grip strength (AD-nLGS, n=25), along with 31 normal controls (NC). General data, neuropsychological tests, grip strength and cranial magnetic resonance imaging (MRI) scans were collected. FBA evaluated white matter (WM) fiber metrics, including fiber density (FD), fiber cross-sectional (FC), and fiber density and cross-sectional area (FDC). The mean fiber indicators of the fiber tracts of interest (TOI) were extracted in cerebral region of significant statistical differences in FBA to further compare the differences between groups and analyze the correlation between fiber properties and neuropsychological test scores.
Results: Compared to AD-nLGS group, AD-LGS group showed significant reductions in FDC in several cerebral regions. In AD patients, FDC values of bilateral uncinate fasciculus and left superior longitudinal fasciculus were positively correlated with Clock Drawing Test scores, while FDC of splenium of corpus callosum, bilateral anterior cingulate tracts, forceps major, and bilateral inferior longitudinal fasciculus were positively correlated with the Executive Factor Score of Memory and Executive Screening scale scores.
Conclusion: Reduced grip strength in AD patients is associated with extensive impairment of WM structural integrity. Changes in FDC of specific WM fiber tracts related to executive function play a significant mediating role in the reduction of grip strength in AD patients.
Keywords: Alzheimer disease, grip strength, white matter, fixel-based analysis, cognition function
中文翻译：
弥合握力减弱和执行功能改变：阿尔茨海默病患者特定的脑白质结构变化
目的：通过基于固定分析（FBA）的方法探讨阿尔茨海默病（AD）患者特定纤维束与握力和认知功能之间的相关性。
方法： AD 患者分为低握力 AD（AD-LGS，n=29）和无低握力 AD（AD-nLGS，n=25），以及 31 名正常对照（NC）。收集一般数据、神经心理学测试、握力和头颅磁共振成像（MRI）扫描。FBA 评估了白质 (WM) 纤维指标，包括纤维密度 (FD)、纤维横截面 (FC) 以及纤维密度和横截面积 (FDC)。提取FBA统计差异显着的大脑区域感兴趣纤维束（TOI）的平均纤维指标，进一步比较组间差异，分析纤维特性与神经心理学测试分数的相关性。
结果：与AD-nLGS组相比，AD-LGS组多个脑区的FDC显着减少。AD患者双侧钩束、左上纵束的FDC值与画钟测试成绩呈正相关，胼胝体压部、双侧前扣带束、钳大束、双侧下纵束的FDC与画钟测试评分呈正相关。记忆执行因素得分和执行筛选量表分数。
结论： AD 患者握力的降低与 WM 结构完整性的广泛损害相关。与执行功能相关的特定 WM 纤维束的 FDC 变化在 AD 患者握力的降低中发挥着重要的中介作用。
关键词:阿尔茨海默病, 握力, 白质, 基于fixel的分析, 认知功能
更新日期：2024-01-16
Methods: AD patients were divided into AD with low grip strength (AD-LGS, n=29) and AD without low grip strength (AD-nLGS, n=25), along with 31 normal controls (NC). General data, neuropsychological tests, grip strength and cranial magnetic resonance imaging (MRI) scans were collected. FBA evaluated white matter (WM) fiber metrics, including fiber density (FD), fiber cross-sectional (FC), and fiber density and cross-sectional area (FDC). The mean fiber indicators of the fiber tracts of interest (TOI) were extracted in cerebral region of significant statistical differences in FBA to further compare the differences between groups and analyze the correlation between fiber properties and neuropsychological test scores.
Results: Compared to AD-nLGS group, AD-LGS group showed significant reductions in FDC in several cerebral regions. In AD patients, FDC values of bilateral uncinate fasciculus and left superior longitudinal fasciculus were positively correlated with Clock Drawing Test scores, while FDC of splenium of corpus callosum, bilateral anterior cingulate tracts, forceps major, and bilateral inferior longitudinal fasciculus were positively correlated with the Executive Factor Score of Memory and Executive Screening scale scores.
Conclusion: Reduced grip strength in AD patients is associated with extensive impairment of WM structural integrity. Changes in FDC of specific WM fiber tracts related to executive function play a significant mediating role in the reduction of grip strength in AD patients.
Keywords: Alzheimer disease, grip strength, white matter, fixel-based analysis, cognition function
中文翻译：
弥合握力减弱和执行功能改变：阿尔茨海默病患者特定的脑白质结构变化
目的：通过基于固定分析（FBA）的方法探讨阿尔茨海默病（AD）患者特定纤维束与握力和认知功能之间的相关性。
方法： AD 患者分为低握力 AD（AD-LGS，n=29）和无低握力 AD（AD-nLGS，n=25），以及 31 名正常对照（NC）。收集一般数据、神经心理学测试、握力和头颅磁共振成像（MRI）扫描。FBA 评估了白质 (WM) 纤维指标，包括纤维密度 (FD)、纤维横截面 (FC) 以及纤维密度和横截面积 (FDC)。提取FBA统计差异显着的大脑区域感兴趣纤维束（TOI）的平均纤维指标，进一步比较组间差异，分析纤维特性与神经心理学测试分数的相关性。
结果：与AD-nLGS组相比，AD-LGS组多个脑区的FDC显着减少。AD患者双侧钩束、左上纵束的FDC值与画钟测试成绩呈正相关，胼胝体压部、双侧前扣带束、钳大束、双侧下纵束的FDC与画钟测试评分呈正相关。记忆执行因素得分和执行筛选量表分数。
结论： AD 患者握力的降低与 WM 结构完整性的广泛损害相关。与执行功能相关的特定 WM 纤维束的 FDC 变化在 AD 患者握力的降低中发挥着重要的中介作用。
关键词:阿尔茨海默病, 握力, 白质, 基于fixel的分析, 认知功能
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