Population data have become available for sequence data to aid forensic investigations and prepare the forensic community in the move towards implementing NGS methods. This comes with a need for updated population genetic parameters estimates to allow DNA evidence evaluations using sequence data. Initial work has been done on a small sample and here we expand this work by providing estimates of population structure and relatedness for autosomal STR data generated by sequencing technologies. We also discuss the effect of inbreeding on forensic calculations and discuss why the use of genotypic-based estimates may be preferred over allelic-based estimates.

中文翻译：

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法医常染色体 STR 标记基于序列的群体结构、相关性和近交估计

群体数据已可用于序列数据，以帮助法医调查并为法医界准备实施 NGS 方法。这就需要更新群体遗传参数估计，以允许使用序列数据进行DNA证据评估。初步工作已经在小样本上完成，在这里我们通过提供测序技术生成的常染色体 STR 数据的群体结构和相关性估计来扩展这项工作。我们还讨论了近亲繁殖对法医计算的影响，并讨论了为什么使用基于基因型的估计可能优于基于等位基因的估计。