Atopic dermatitis (AD) is an inflammatory skin disease characterized by intense pruritus. AD is harmful to both children and adults, but its pathogenic mechanism has yet to be fully elucidated. The development of mouse models for AD has greatly contributed to its study and treatment. Among these models, the exogenous drug-induced mouse model has shown promising results and significant advantages. Until now, a large amount of AD-related research has utilized exogenous drug-induced mouse models, leading to notable advancements in research. This indicates the crucial significance of applying such models in AD research. These models exhibit diverse characteristics and are highly complex. They involve the use of various strains of mice, diverse types of inducers, and different modeling effects. However, there is currently a lack of comprehensive comparative studies on exogenous drug-induced AD mouse models, which hinders researchers' ability to choose among these models. This paper provides a comprehensive review of the features and mechanisms associated with various exogenous drug-induced mouse models, including the important role of each cytokine in AD development. It aims to assist researchers in quickly understanding models and selecting the most suitable one for further investigation.

特应性皮炎（AD）是一种以剧烈瘙痒为特征的炎症性皮肤病。AD对儿童和成人都有危害，但其致病机制尚未完全阐明。AD小鼠模型的开发极大地促进了AD的研究和治疗。在这些模型中，外源性药物诱导的小鼠模型已显示出良好的结果和显着的优势。迄今为止，大量AD相关研究都利用了外源性药物诱导的小鼠模型，取得了显着的研究进展。这表明将此类模型应用于AD研究中至关重要的意义。这些模型表现出不同的特征并且非常复杂。它们涉及使用不同品系的小鼠、不同类型的诱导剂和不同的建模效果。然而，目前缺乏对外源性药物诱导的AD小鼠模型的全面比较研究，这阻碍了研究人员在这些模型中进行选择的能力。本文全面综述了各种外源性药物诱导小鼠模型的特征和机制，包括每种细胞因子在 AD 发展中的重要作用。它旨在帮助研究人员快速理解模型并选择最合适的模型进行进一步研究。