This study aimed to investigate the prevalence and characteristics of diabetic symmetric sensorimotor polyneuropathy (DSPN) in patients with type 2 diabetes registered in the Japan Diabetes Complication and its Prevention Prospective study. In the study, 6,338 patients with diabetes who had been treated by diabetes specialists were registered in 2007–2009. Of these, patients with type 2 diabetes who could be evaluated for DSPN were analyzed using the t-test, χ²-test and logistic regression analyses. DSPN was diagnosed using the Simple Diagnostic Criteria for Diabetic Polyneuropathy proposed by the Diabetic Neuropathy Study Group in Japan. Of the total participants, 5,451 patients (mean age 61.4 years, duration of diabetes 10.8 years) were analyzed. Based on the criteria, 35.8% of patients were diagnosed with DSPN. The prevalence of sensory symptoms was 25.8%. The following factors increased the risk for DSPN: age (odds ratio [OR] 1.57, 95% confidence interval [CI] 1.42–1.73), duration of diabetes (OR 1.32, 95% CI 1.21–1.43), body mass index (OR 1.19, 95% CI 1.09–1.30), systolic blood pressure (OR 1.06, 95% CI 1.01–1.10), hemoglobin A1c (OR 1.15, 95% CI 1.09–1.22), biguanides (OR 1.22, 95% CI 1.06–1.39) and insulin therapy (OR 1.59, 95% CI 1.36–1.84). The following factors decreased the risk for DSPN: total cholesterol (OR 0.98, 95% CI 0.96–1.00) and exercise therapy (OR 0.85, 95% CI 0.73–0.98). The baseline survey clarified the prevalence and characteristics of DSPN in Japanese patients with type 2 diabetes. The survey also showed the risk factors of DSPN.

中文翻译：

---

日本 2 型糖尿病患者糖尿病对称性感觉运动性多发性神经病的患病率和特征：日本糖尿病并发症及其预防前瞻性研究（JDCP 研究 10）

本研究旨在调查日本糖尿病并发症及其预防前瞻性研究中登记的 2 型糖尿病患者中糖尿病对称性感觉运动多发性神经病 (DSPN) 的患病率和特征。该研究登记了 2007 年至 2009 年期间接受过糖尿病专家治疗的 6,338 名糖尿病患者。其中，可以评估 DSPN 的 2 型糖尿病患者使用t检验、χ ²检验和逻辑回归分析进行分析。DSPN 的诊断采用日本糖尿病神经病研究小组提出的糖尿病多发性神经病简单诊断标准。在所有参与者中，对 5,451 名患者（平均年龄 61.4 岁，糖尿病病程 10.8 年）进行了分析。根据标准，35.8%的患者被诊断为DSPN。感觉症状的患病率为25.8%。以下因素增加了 DSPN 的风险：年龄（优势比 [OR] 1.57，95% 置信区间 [CI] 1.42–1.73）、糖尿病病程（OR 1.32，95% CI 1.21–1.43）、体重指数（OR 1.19，95% CI 1.09–1.30)、收缩压（OR 1.06，95% CI 1.01–1.10）、糖化血红蛋白（OR 1.15，95% CI 1.09–1.22）、双胍类药物（OR 1.22，95% CI 1.06–1.39） ）和胰岛素治疗（OR 1.59，95% CI 1.36–1.84）。以下因素可降低 DSPN 风险：总胆固醇（OR 0.98，95% CI 0.96–1.00）和运动疗法（OR 0.85，95% CI 0.73–0.98）。基线调查阐明了日本 2 型糖尿病患者 DSPN 的患病率和特征。调查还显示了DSPN的危险因素。