Teaching chemistry and biology students about biologics design remains challenging despite its increasing importance in pharmaceutical development. Monoclonal antibodies, commonly called mAbs, are the most popular biologics. They have been developed into drugs to treat various diseases in the past decades. Multiple challenges exist for designing proper formulations to stabilize mAbs, such as preventing aggregation and mitigating viscosity. Molecular modeling and simulations can improve pharmaceutical products by examining the interactions between mAbs and other compounds, such as excipients. To introduce students to biopharmaceuticals, eight students at the Stevens Institute of Technology participated in a semester-long course to learn the challenges of pharmaceutical development and different computational skills to study biologics design. The students started with a limited background in this field. Throughout one semester, they were introduced to various literature and software tools for modeling antibodies and studying their interactions with excipients. This paper aims to develop a course structure to be replicated at other universities and institutions to teach biopharmaceutical development to students.

中文翻译：

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使用分子建模和模拟教授生物制剂设计

尽管生物制剂设计在药物开发中越来越重要，但向化学和生物学学生教授生物制剂设计仍然具有挑战性。单克隆抗体，通常称为 mAb，是最流行的生物制剂。在过去的几十年里，它们已被开发成治疗各种疾病的药物。设计适当的制剂来稳定单克隆抗体存在多种挑战，例如防止聚集和减轻粘度。分子建模和模拟可以通过检查单克隆抗体与其他化合物（例如赋形剂）之间的相互作用来改进药品。为了向学生介绍生物制药，史蒂文斯理工学院的八名学生参加了为期一个学期的课程，以了解药物开发的挑战以及研究生物制剂设计的不同计算技能。学生们一开始在该领域的背景有限。在一个学期的时间里，他们学习了各种文献和软件工具，用于对抗体进行建模并研究它们与赋形剂的相互作用。本文旨在开发一种可在其他大学和机构复制的课程结构，向学生教授生物制药开发。