Abstract

Hair graying, also known as canities or achromotrichia, is a natural phenomenon associated with aging and is influenced by external factors such as stress, environmental toxicants, and radiation exposure. Understanding the mechanisms underlying hair graying is an ideal approach for developing interventions to prevent or reverse age-related changes in regenerative tissues. Hair graying induced by ionizing radiation (γ-rays or X-rays) has emerged as a valuable experimental model to investigate the molecular pathways involved in this process. In this review, we examine the existing evidence on radiation-induced hair graying, with a particular focus on the potential role of radiation-induced cellular senescence. We explore the current understanding of hair graying in aging, delve into the underlying mechanisms, and highlight the unique advantages of using ionizing-irradiation–induced hair graying as a research model. By elucidating the molecular pathways involved, we aim to deepen our understanding of hair graying and potentially identify novel therapeutic targets to address this age-related phenotypic change.

中文翻译：

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辐射引起的小鼠头发变白：评估氧化应激、DNA 损伤预防和细胞衰老干预措施有效性的实验模型

摘要

头发变白，也称为白发或无色，是一种与衰老相关的自然现象，受到压力、环境毒物和辐射等外部因素的影响。了解头发变白的机制是制定干预措施以预防或逆转再生组织中与年龄相关的变化的理想方法。电离辐射（γ 射线或 X 射线）引起的头发变白已成为研究该过程中涉及的分子途径的有价值的实验模型。在这篇综述中，我们研究了辐射引起的头发变白的现有证据，特别关注辐射引起的细胞衰老的潜在作用。我们探讨了目前对衰老过程中头发变白的理解，深入研究了潜在的机制，并强调了使用电离辐射引起的头发变白作为研究模型的独特优势。通过阐明所涉及的分子途径，我们的目标是加深对头发变白的理解，并可能确定新的治疗靶点来解决这种与年龄相关的表型变化。